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Application of high-field NMR and cryogenic probe technologies in the structural elucidation of poecillastrin a, a new antitumor macrolide lactam from the sponge poecillastra species

Authors :
Ronald C. Crouch
Lewis K. Pannell
Que N. Van
Mohammad A Rashid
Amiram Groweiss
Kirk R. Gustafson
Michael R. Boyd
Source :
Organic letters. 4(19)
Publication Year :
2002

Abstract

Poecillastrin A (1), a new polyketide-derived macrolide lactam, was isolated from a deep-water collection of the marine sponge Poecillastra species. The structure of poecillastrin A (1) was assigned using NMR data acquired at 500 MHz with an inverse-detection cryogenic probe and at 800 MHz with a room-temperature probe.

Details

ISSN :
15237060
Volume :
4
Issue :
19
Database :
OpenAIRE
Journal :
Organic letters
Accession number :
edsair.doi.dedup.....bc9bb2d3004e37ece4da8a07af2f7b68