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Pioglitazone improves insulin resistance and decreases blood pressure in adult patients with congenital adrenal hyperplasia
- Source :
- European Journal of Endocrinology, 161, 887-94, European Journal of Endocrinology, 161, 6, pp. 887-94
- Publication Year :
- 2009
- Publisher :
- Oxford University Press (OUP), 2009.
-
Abstract
- ContextPatients with congenital adrenal hyperplasia (CAH) are chronically treated with supraphysiological doses of glucocorticoids, which are known to induce insulin resistance. Thiazolidinediones might reverse this effect and improve insulin sensitivity.ObjectivesTo assess insulin sensitivity in CAH patients and the effect of pioglitazone treatment on insulin sensitivity in CAH patients. Secondary objectives were the effects of treatment with pioglitazone on blood pressure, body fat distribution, lipid, and steroid profiles.DesignRandomized placebo controlled crossover trial.ParticipantsTwelve CAH patients and 12 body mass and age-matched control subjects.InterventionSixteen-week treatment with pioglitazone (45 mg/day) or placebo.Main outcome measureInsulin sensitivity measured by euglycemic clamp and oral glucose tolerance test. Further measures were 24-h blood pressure profiles, body fat distribution measured by magnetic resonance imaging, dual energy x-ray absorptiometry (DEXA) and bioimpedance procedures, liver fat by magnetic resonance spectroscopy, lipid, and steroid profiles.ResultsCAH patients were insulin resistant compared with healthy controls. Treatment with pioglitazone significantly improved insulin sensitivity in CAH patients (glucose infusion rate (GIR) from 28.5±11.6 to 38.9±11.0 μmol/kg per min, P=0.000, GIR in controls 46.2±23.4 μmol/kg per min, PPPConclusionsCAH patients are insulin resistant compared with matched control subjects. Treatment with pioglitazone improves insulin sensitivity and decreases blood pressure in CAH patients.
- Subjects :
- Adult
Male
medicine.medical_specialty
Health aging / healthy living [IGMD 5]
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Hemodynamics
Blood Pressure
Endocrinology
Insulin resistance
Internal medicine
medicine
Humans
Hypoglycemic Agents
Pancreatic hormone
Cross-Over Studies
Adrenal Hyperplasia, Congenital
Pioglitazone
business.industry
Insulin
Hormonal regulation [IGMD 6]
Functional imaging [IGMD 1]
General Medicine
Middle Aged
medicine.disease
Lipids
Crossover study
Blood pressure
Adipose Tissue
Liver
Decreased blood pressure
Female
Thiazolidinediones
Insulin Resistance
business
medicine.drug
Subjects
Details
- ISSN :
- 1479683X and 08044643
- Volume :
- 161
- Database :
- OpenAIRE
- Journal :
- European Journal of Endocrinology
- Accession number :
- edsair.doi.dedup.....bc965fbc09baf39562038a05bf0cc1b4