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X-treme loss of sequence diversity linked to neo-X chromosomes in filarial nematodes
- Source :
- PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009838 (2021), PLoS Neglected Tropical Diseases, PLoS Neglected Tropical Diseases, Vol 15, Iss 10 (2021)
- Publication Year :
- 2021
- Publisher :
- Public Library of Science, 2021.
-
Abstract
- The sequence diversity of natural and laboratory populations of Brugia pahangi and Brugia malayi was assessed with Illumina resequencing followed by mapping in order to identify single nucleotide variants and insertions/deletions. In natural and laboratory Brugia populations, there is a lack of sequence diversity on chromosome X relative to the autosomes (πX/πA = 0.2), which is lower than the expected (πX/πA = 0.75). A reduction in diversity is also observed in other filarial nematodes with neo-X chromosome fusions in the genera Onchocerca and Wuchereria, but not those without neo-X chromosome fusions in the genera Loa and Dirofilaria. In the species with neo-X chromosome fusions, chromosome X is abnormally large, containing a third of the genetic material such that a sizable portion of the genome is lacking sequence diversity. Such profound differences in genetic diversity can be consequential, having been associated with drug resistance and adaptability, with the potential to affect filarial eradication.<br />Author summary Almost a billion people receive >7.7 billion doses of treatment aimed at eliminating lymphatic filariasis, which is caused by three filarial nematodes: Wuchereria bancrofti, Brugia malayi, and Brugia timori. Drug resistance and adaptation are both associated with pathogen success as well as higher levels of genetic diversity. In an examination of genetic diversity in Brugia malayi and Brugia pahangi, we observed a lack of genetic diversity over a third of the genome that is found on chromosome X. These species have neo-X chromosomes where a chromosome X fused with an autosome. Using publicly-available published data, the other filarial nematodes of greatest human significance are also found to have a similar lack of genetic diversity on their neo-X chromosomes. The two filarial nematodes with publicly-available data that lack neo-X chromosomes did not have this lack of genetic diversity. This lack of sequence diversity in B. malayi, W. bancrofti, and O. volvulus could have profound effects on all traits encoded on chromosome X.
- Subjects :
- Nematoda
RC955-962
Genome
Brugia malayi
qx_301
Arctic medicine. Tropical medicine
Invertebrate Genomics
Onchocerca
Brugia Malayi
X chromosome
Genetics
Sex Chromosomes
biology
Ecology
Chromosome Biology
Autosomes
Eukaryota
X Chromosomes
Genomics
wc_850
Infectious Diseases
Public aspects of medicine
RA1-1270
Research Article
Brugia pahangi
X Chromosome
Ecological Metrics
Chromosomes
Helminths
parasitic diseases
Brugia
Animals
Chromosome Aberrations
Genetic diversity
Evolutionary Biology
Genome, Helminth
Autosome
Population Biology
Ecology and Environmental Sciences
Public Health, Environmental and Occupational Health
Organisms
Chromosome
Biology and Life Sciences
Genetic Variation
Species Diversity
Cell Biology
biology.organism_classification
Invertebrates
Animal Genomics
Onchocerca Volvulus
qu_470
Zoology
human activities
Population Genetics
Subjects
Details
- Language :
- English
- ISSN :
- 19352735
- Database :
- OpenAIRE
- Journal :
- PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009838 (2021), PLoS Neglected Tropical Diseases, PLoS Neglected Tropical Diseases, Vol 15, Iss 10 (2021)
- Accession number :
- edsair.doi.dedup.....bc94a3b2c04ce343662e1516547dbc54