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Analysis of elderly patients with diffuse large B-cell lymphoma: aggressive therapy is a reasonable approach for ‘unfit’ patients classified by comprehensive geriatric assessment
- Source :
- European Journal of Haematology. 96:409-416
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Background The treatment strategy for diffuse large B-cell lymphoma (DLBCL) in elderly patients is problematic. Although several researchers have reported the effectiveness of comprehensive geriatric assessment (CGA) and the futility of curative treatment in ‘unfit’ patients with DLBCL, these propositions are not firmly established. Patients and methods We conducted a retrospective analysis using a database. Patients with DLBCL were eligible if ≧ 60 yr old. CGA stratification was performed using medical records. Results One hundred and 35 patients were identified. Anthracycline-based chemotherapy with curative intent was performed in 115 (85%) patients. According to CGA, 82 (61%) patients were classified as ‘fit’. Their 1-yr overall survival (OS) was significantly better than that of ‘unfit’ patients [91.3% vs. 53.8%, P
- Subjects :
- Male
endocrine system
medicine.medical_specialty
Anthracycline
medicine.medical_treatment
03 medical and health sciences
0302 clinical medicine
Older patients
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Overall survival
Humans
Cyclophosphamide
Geriatric Assessment
Aged
Retrospective Studies
Aged, 80 and over
Chemotherapy
business.industry
Patient Selection
Medical record
Palliative Care
Geriatric assessment
Hematology
General Medicine
Middle Aged
Prognosis
medicine.disease
Survival Analysis
Surgery
Lymphoma
Treatment Outcome
Doxorubicin
Vincristine
030220 oncology & carcinogenesis
Prednisone
Female
Lymphoma, Large B-Cell, Diffuse
business
Diffuse large B-cell lymphoma
030215 immunology
Subjects
Details
- ISSN :
- 09024441
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- European Journal of Haematology
- Accession number :
- edsair.doi.dedup.....bc922e60da953d5093045c64b60f68a7