Back to Search
Start Over
Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques
- Source :
- Zoological Research, Zoological Research, Vol 41, Iss 5, Pp 503-516 (2020)
- Publication Year :
- 2020
- Publisher :
- Science Press, 2020.
-
Abstract
- As of June 2020, Coronavirus Disease 2019 (COVID-19) has killed an estimated 440 000 people worldwide, 74% of whom were aged ≥65 years, making age the most significant risk factor for death caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To examine the effect of age on death, we established a SARS-CoV-2 infection model in Chinese rhesus macaques ( Macaca mulatta) of varied ages. Results indicated that infected young macaques manifested impaired respiratory function, active viral replication, severe lung damage, and infiltration of CD11b + and CD8 + cells in lungs at one-week post infection (wpi), but also recovered rapidly at 2 wpi. In contrast, aged macaques demonstrated delayed immune responses with a more severe cytokine storm, increased infiltration of CD11b + cells, and persistent infiltration of CD8 + cells in the lungs at 2 wpi. In addition, peripheral blood T cells from aged macaques showed greater inflammation and chemotaxis, but weaker antiviral functions than that in cells from young macaques. Thus, the delayed but more severe cytokine storm and higher immune cell infiltration may explain the poorer prognosis of older aged patients suffering SARS-CoV-2 infection.
- Subjects :
- 0301 basic medicine
Aging
T-Lymphocytes
Pneumonia, Viral
Inflammation
Severe Acute Respiratory Syndrome
Virus Replication
03 medical and health sciences
Betacoronavirus
0302 clinical medicine
Immune system
Elderly
lcsh:Zoology
medicine
Animals
lcsh:QL1-991
Immune response
Lung
Pandemics
Ecology, Evolution, Behavior and Systematics
Ecology
business.industry
SARS-CoV-2
Monkey Diseases
Age Factors
COVID-19
Non-human primate animal model
Articles
Viral Load
medicine.disease
Macaca mulatta
030104 developmental biology
medicine.anatomical_structure
Viral replication
Immunology
Cytokines
Animal Science and Zoology
medicine.symptom
Cytokine storm
business
Coronavirus Infections
Viral load
Infiltration (medical)
030217 neurology & neurosurgery
CD8
Subjects
Details
- Language :
- English
- ISSN :
- 20958137
- Volume :
- 41
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Zoological Research
- Accession number :
- edsair.doi.dedup.....bc8f6827a7c530197435c0f4c85c1188