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Donor acute kidney injury and its effect on 1‐year post‐transplant kidney allograft fibrosis
- Source :
- Clinical Transplantation. 34
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Transplantation of kidneys from deceased donors with acute kidney injury (AKI) can expand the donor pool. We investigated the effect of donor AKI on renal function and chronic changes on protocol biopsies at 1-year post-transplant. Donor AKI was defined according to Acute Kidney Injury Network (AKIN) criteria. Between 2013 and 2017, 333 kidneys were transplanted and subsequently biopsied after 1 year. Fifty-three kidneys from AKI donors (AKIN stage I n = 42, stage II n = 8, stage III n = 3) were compared to 280 kidneys from non-AKI donors. At 1-year follow-up, patient and graft survival were comparable. Donor AKI was not predictive of IFTA (Banff interstitial fibrosis plus tubular atrophy scores) at 1-year post-transplant biopsy (2.10 ± 1.28 in AKI, 2.09 ± 1.22 in non-AKI, P = .95). Donor AKI was also not associated with progression of IFTA from 3 to 12 months (P = .69), or inferior glomerular filtration rate (eGFR, P = .94). In a multivariate analysis, the odds of IFTA >2 were comparable between AKI and non-AKI groups. In conclusion, the transplantation of kidneys from donors with predominantly stage I AKI results in comparable function and degree of fibrosis on protocol biopsies 1-year post-transplant. Selected grafts from donors with AKI are a valuable tool for expanding the donor pool for kidney transplantation.
- Subjects :
- medicine.medical_specialty
Urology
Delayed Graft Function
Renal function
Kidney
urologic and male genital diseases
Fibrosis
Biopsy
medicine
Humans
Stage (cooking)
Kidney transplantation
Retrospective Studies
Transplantation
medicine.diagnostic_test
urogenital system
business.industry
Graft Survival
Acute kidney injury
Acute Kidney Injury
Allografts
medicine.disease
Tissue Donors
female genital diseases and pregnancy complications
medicine.anatomical_structure
business
Subjects
Details
- ISSN :
- 13990012 and 09020063
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Clinical Transplantation
- Accession number :
- edsair.doi.dedup.....bc8aac774c643a9b2b138465ea407e67