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Early Morphofunctional Changes in AngII-Infused Mice Contribute to Regional Onset of Aortic Aneurysm and Dissection
- Source :
- Journal of vascular research
- Publisher :
- KARGER
-
Abstract
- Aortic aneurysms and dissections are silent and lethal conditions, whose pathogenesis remains incompletely understood. Although angiotensin II (AngII)-infused ApoE−/− mice have been widely used to study aortic aneurysm and dissection, early morphofunctional alterations preceding the onset of these conditions remain unknown. The goal of this study was to unveil early morphofunctional changes underlying the onset of aneurysm and dissection. At 3 days post-AngII infusion, suprarenal abdominal aorta presented significant volumetric dilatation and microstructural damage. Ex vivo assessment of vascular reactivity of the suprarenal dissection-prone aorta and its side branches, showed an endothelial and contractile dysfunctions that were severe in the suprarenal aorta, moderate distally, and absent in the side branches, mirroring the susceptibility to dissection of these different vascular segments. Early and specific morphofunctional changes of the suprarenal aorta may contribute to the regional onset of aortic aneurysm and dissection by exacerbating the biomechanical burden arising from its side branches.
- Subjects :
- medicine.medical_specialty
vascular reactivity
hypertension
Physiology
angiotensin ii
contractility
Article
Aortic aneurysm
Aneurysm
Internal medicine
medicine.artery
Suprarenal Aorta
synchrotron
medicine
aortic dissection
angiotensin-ii
Aortic dissection
Aorta
mechanisms
business.industry
Abdominal aorta
medicine.disease
Angiotensin II
Dissection
Cardiology
cardiovascular system
Cardiology and Cardiovascular Medicine
business
aortic aneurysm
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Journal of vascular research
- Accession number :
- edsair.doi.dedup.....bc681b055cf1cd5b7a5628d9022d0c05