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Bone marrow and blood involvement by non-Hodgkin's lymphoma: A study of clinicopathologic correlations and prognostic significance in relationship to the Working Formulation
- Source :
- Europe PubMed Central
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- In a series of 172 patients with non-Hodgkin's lymphoma (NHL) classified according to the Working Formulation (WF) the overall incidence of bone marrow infiltration (BM +) at diagnosis was 39%: 59% for low-grade (LGML), 30% for intermediate-grade (IGML), and 25% for high-grade malignant lymphomas (HGML). The features most significantly correlated with the presence of BM + were a low grade of histological malignancy, the degree of splenomegaly and high values of LDH, while those correlated with the extent of BM+ were a non-focal pattern of BM disease, the presence of blood involvement at diagnosis, and the degree of BM fibrosis. Blood involvement was detected at diagnosis in 13% of patients, and a further 16% developed a leukemic phase during the course of the disease. Blood involvement correlated significantly with splenomegaly, bulky disease, advanced clinical stage, and extent of BM +. The presence of BM infiltration ‘per se’ at diagnosis did not significantly affect prognosis. However, the extent of BM disease was correlated with a poorer outcome in IGML and HGML patients. Regarding peripheral blood involvement, in LGML patients only late leukemic conversions were significantly associated with a worse prognosis. In patients with IGML and HGML, either initial or subsequent blood involvement was correlated with significantly poorer outcome.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Working Formulation
Adolescent
Disease
Malignancy
Gastroenterology
Bleomycin
Actuarial Analysis
Fibrosis
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Neoplasm Invasiveness
Cyclophosphamide
Aged
business.industry
Lymphoma, Non-Hodgkin
Hematology
General Medicine
Middle Aged
Prognosis
medicine.disease
Lymphoma
Non-Hodgkin's lymphoma
medicine.anatomical_structure
Doxorubicin
Vincristine
Prednisone
Female
Bone marrow
business
Infiltration (medical)
Follow-Up Studies
Subjects
Details
- ISSN :
- 16000609 and 09024441
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- European Journal of Haematology
- Accession number :
- edsair.doi.dedup.....bc65526c1ca6f2671e51096bd33b7739