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Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers
- Source :
- Journal of Immunology, Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2002, 169 (9), pp.4850-60. ⟨10.4049/jimmunol.169.9.4850⟩, Journal of Immunology, 2002, 169 (9), pp.4850-60. ⟨10.4049/jimmunol.169.9.4850⟩, Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2002, 169 (9), pp.4850-60, Journal of immunology (Baltimore, Md., 169(9), 4850-4860. American Association of Immunologists
- Publication Year :
- 2002
- Publisher :
- The American Association of Immunologists, 2002.
-
Abstract
- We show that the lymphoid hyperplasia observed in IL-2Rα- and IL-2-deficient mice is due to the lack of a population of regulatory cells essential for CD4 T cell homeostasis. In chimeras reconstituted with bone marrow cells from IL-2Rα-deficient donors, restitution of a population of CD25+CD4+ T cells prevents the chaotic accumulation of lymphoid cells, and rescues the mice from autoimmune disease and death. The reintroduction of IL-2-producing cells in IL-2-deficient chimeras establishes a population of CD25+CD4+ T cells, and restores the peripheral lymphoid compartments to normal. The CD25+CD4+ T cells regulated selectively the number of naive CD4+ T cells transferred into T cell-deficient hosts. The CD25+CD4+/naive CD4 T cell ratio and the sequence of cell transfer determines the homeostatic plateau of CD4+ T cells. Overall, our findings demonstrate that IL-2Rα is an absolute requirement for the development of the regulatory CD25+CD4+ T cells that control peripheral CD4 T cell homeostasis, while IL-2 is required for establishing a sizeable population of these cells in the peripheral pools.
- Subjects :
- CD4-Positive T-Lymphocytes
MESH: Adjuvants, Immunologic
MESH: T-Lymphocyte Subsets
MESH: Mice, Knockout
MESH : Radiation Chimera
Mice
Interleukin 21
0302 clinical medicine
T-Lymphocyte Subsets
[ SDV.IMM ] Life Sciences [q-bio]/Immunology
Homeostasis
Immunology and Allergy
Cytotoxic T cell
MESH: Animals
IL-2 receptor
MESH: Bone Marrow Transplantation
MESH : Lymphocyte Count
Bone Marrow Transplantation
Mice, Knockout
0303 health sciences
MESH : Interphase
ZAP70
MESH: CD4-Positive T-Lymphocytes
CD28
Natural killer T cell
Cell biology
MESH: Homeostasis
MESH : CD4-Positive T-Lymphocytes
MESH : Homeostasis
Radiation Chimera
MESH: Survival Analysis
[SDV.IMM]Life Sciences [q-bio]/Immunology
MESH : Lymphopenia
MESH: Lymphocyte Count
MESH: Radiation Chimera
Immunology
MESH : Mice, Inbred C57BL
Biology
MESH : Interleukin-2
MESH: Receptors, Interleukin-2
MESH: Interphase
MESH: Lymphopenia
03 medical and health sciences
Adjuvants, Immunologic
MESH: Mice, Inbred C57BL
MESH : Receptors, Interleukin-2
Lymphopenia
MESH : Mice
Animals
Lymphocyte Count
Antigen-presenting cell
Interphase
MESH: Mice
030304 developmental biology
Interleukin 3
MESH : Bone Marrow Transplantation
Receptors, Interleukin-2
MESH: Interleukin-2
Survival Analysis
MESH : T-Lymphocyte Subsets
Mice, Inbred C57BL
MESH : Adjuvants, Immunologic
MESH : Mice, Knockout
Interleukin-2
MESH : Animals
MESH : Survival Analysis
030215 immunology
Subjects
Details
- ISSN :
- 15506606 and 00221767
- Volume :
- 169
- Database :
- OpenAIRE
- Journal :
- The Journal of Immunology
- Accession number :
- edsair.doi.dedup.....bc5dd88a962005b9b0c7e534bc0c70aa