Back to Search
Start Over
Characterization of Biomarkers in Polycystic Ovary Syndrome (PCOS) Using Multiple Distinct Proteomic Platforms
- Source :
- Journal of Proteome Research. 6:3321-3328
- Publication Year :
- 2007
- Publisher :
- American Chemical Society (ACS), 2007.
-
Abstract
- A variety of prefractionation methods (including a novel reversed-phase solid-phase-extraction (RP-SPE) combined with SDS-PAGE and proteomic based approaches (e.g., 2-dimensional gel electrophoresis (2DE) and MALDI-TOF mass spectrometry combined with Artificial Neural Network (ANN) bioinformatic tools) were used to investigate the protein/peptide signatures in patients with Polycystic Ovary Syndrome (PCOS). Four potential PCOS biomarkers were identified (complement C4alpha3c and C4gamma and haptoglobin alpha and beta chains).
- Subjects :
- Gel electrophoresis
Proteome
Polycystic ovary syndrome (PCOS)
Haptoglobin
General Chemistry
Biology
medicine.disease
Bioinformatics
Biochemistry
Polycystic ovary
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
medicine
biology.protein
Humans
Electrophoresis, Gel, Two-Dimensional
Female
In patient
Biomarkers
Polycystic Ovary Syndrome
Subjects
Details
- ISSN :
- 15353907 and 15353893
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of Proteome Research
- Accession number :
- edsair.doi.dedup.....bc5dc2a863645a3608eefa942152f06b