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High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma
- Source :
- Nature Medicine, 21(1), 81-85, Nature medicine, 21(1), 81-85. Nature Publishing Group
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- Tumor-specific neo-antigens that arise as a consequence of mutations(1,2) are thought to be important for the therapeutic efficacy of cancer immunotherapies(3-5). Accumulating evidence suggests that neo-antigens may be commonly recognized by intratumoral CD8(+) T cells(3-7), but it is unclear whether neoantigen-specific CD4(+) T cells also frequently reside within human tumors. In view of the accepted role of tumor-specific CD4(+) T-cell responses in tumor control(8-10), we addressed whether neo-antigen-specific CD4(+) T-cell reactivity is a common property in human melanoma
- Subjects :
- CD4-Positive T-Lymphocytes
medicine.medical_treatment
bcl-X Protein
Epitopes, T-Lymphocyte
CD8-Positive T-Lymphocytes
Biology
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
Epitope
Antigen
Cancer immunotherapy
Antigens, Neoplasm
Cell Line, Tumor
medicine
Humans
Melanoma
Antigen Presentation
Mutation
Cancer
General Medicine
Immunotherapy
medicine.disease
DNA-Binding Proteins
Immunology
Proto-Oncogene Proteins c-bcl-6
CD8
Subjects
Details
- ISSN :
- 1546170X and 10788956
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Nature Medicine
- Accession number :
- edsair.doi.dedup.....bc5b349490337de7cdb62cb22e6ee9cd