Background factors in patients receiving immunoglobulin administration and changes in sepsis markers

The potentially envisaged actions of intravenous immunoglobulin (IVIg) on severe infectious disease include virus or toxin neutralizing action, opsonic effect, complement bacteriolytic activity, and enhancement of sensitivity to antibiotics. In the case of severe infectious disease, antibiotics are often supplemented with administration of IVIg. The aim of this study is that the changes in sepsis markers followed by IVIg administration are investigated with severe sepsis or severe septic shock patients.