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Endothelial function in children with a history of premature prolonged rupture of membranes and bronchopulmonary dysplasia – a pilot study
- Source :
- Acta Paediatrica. 97:909-914
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- Aim: To investigate vascular function in children with a neonatal history of generalised inflammation indicated by premature prolonged rupture of membranes (PPROM) and bronchopulmonary dysplasia (BPD). Methods: Children born at ≤ 30 weeks 1994–2000 were investigated at a present age of 6–12 years. Twenty-eight children participated and were divided into two groups with regard to BPD/no BPD (n = 15/13) and PPROM/no PPROM (n = 10/18). Vascular endothelial function was assessed by acetylcholine (ACh)-induced skin vasodilatation. Results: Maximum ACh-induced skin perfusion was statistically significantly lower in the PPROM group compared with the non-PPROM group (p = 0.045) after adjustment for confounders. We found no association between BPD and maximum ACh-induced skin perfusion (p = 0.404), after adjustment for confounders. Conclusion: A neonatal history of prolonged premature rupture of membranes was associated with later impairment of vascular endothelial function in childhood. This association was not observed with BPD. Some forms of perinatal inflammation may be associated with later cardiovascular function.
- Subjects :
- Male
Fetal Membranes, Premature Rupture
medicine.medical_specialty
Pediatrics
Endothelium
Vasodilator Agents
Inflammation
Gastroenterology
Pregnancy
Internal medicine
mental disorders
medicine
Humans
Rupture of membranes
Child
Bronchopulmonary Dysplasia
Skin
business.industry
Respiratory disease
Infant, Newborn
General Medicine
medicine.disease
Acetylcholine
Vasodilation
medicine.anatomical_structure
Bronchopulmonary dysplasia
El Niño
Pediatrics, Perinatology and Child Health
Female
Endothelium, Vascular
medicine.symptom
business
Premature rupture of membranes
Infant, Premature
Follow-Up Studies
Subjects
Details
- ISSN :
- 16512227 and 08035253
- Volume :
- 97
- Database :
- OpenAIRE
- Journal :
- Acta Paediatrica
- Accession number :
- edsair.doi.dedup.....bc46ee25645cfae8ae67817dc1c3f470