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Simulation of Low Density Lipoprotein (LDL) permeation into multilayer coronary arterial wall: Interactive effects of wall shear stress and fluid-structure interaction in hypertension
- Source :
- Journal of Biomechanics. 67:114-122
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Due to increased atherosclerosis-caused mortality, identification of its genesis and development is of great importance. Although, key factors of the origin of the disease is still unknown, it is widely believed that cholesterol particle penetration and accumulation in arterial wall is mainly responsible for further wall thickening and decreased rate of blood flow during a gradual progression. To date, various effective components are recognized whose simultaneous consideration would lead to a more accurate approximation of Low Density Lipoprotein (LDL) distribution within the wall. In this research, a multilayer Fluid-Structure Interaction (FSI) model is studied to simulate the penetration of LDL into the arterial wall. Distention impact on wall properties is taken into account by considering FSI and Wall Shear Stress (WSS) dependent endothelium properties. The results show intensified permeation of LDL whilst the FSI approach is applied. In addition, luminal distension prompted by FSI reduces WSS along lumen/wall interface, especially in hypertension. This effect leads to a lowered endothelial resistance against LDL permeation, comparing to the case in which WSS effect is overlooked. The results are in an acceptable consistency with the clinical researches on WSS effect on atherosclerosis development.
- Subjects :
- Endothelium
0206 medical engineering
Biomedical Engineering
Biophysics
02 engineering and technology
030204 cardiovascular system & hematology
Distension
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Shear stress
medicine
Orthopedics and Sports Medicine
Cholesterol
Rehabilitation
Hemodynamics
Models, Cardiovascular
Blood flow
Penetration (firestop)
Permeation
Coronary Vessels
020601 biomedical engineering
Lipoproteins, LDL
medicine.anatomical_structure
chemistry
Low-density lipoprotein
Hypertension
Stress, Mechanical
Shear Strength
Subjects
Details
- ISSN :
- 00219290
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Journal of Biomechanics
- Accession number :
- edsair.doi.dedup.....bc310e7903382f5bdfa9c321a4b5a9b1