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Identification of predictive factors for early neoplasia in Barrett's esophagus after autofluorescence imaging: a stepwise multicenter structured assessment
- Source :
- Gastrointestinal endoscopy, 70(1), 9-17. Mosby Inc.
- Publication Year :
- 2008
-
Abstract
- Background: Autofluorescence imaging is a novel imaging technique that may improve the detection of early, neoplasia in Barrett's esophagus. Autofluorescence imaging is, however, associated with a 40% to 81% false-positive rate. Objective: Our purpose was to identify endoscopic features that may predict the presence of early neoplasia in autofluorescence-positive areas. Design: Descriptive and prospective cohort study. Setting: Tertiary referral centers for the detection and treatment of early Barrett's neoplasia. Patients and Methods: Patients Undergoing autofluorescence endoscopy High-quality images with autofluorescence imaging and white-light endoscopy were obtained with corresponding histologic study A systematic image evaluation process was performed, including an unblinded orientation phase (10 areas), a blinded derivation phase, and a blinded validation phase by 5 international experts in autofluorescence imaging (80 areas). Subsequently the identified features were validated in a prospective pilot study. Main Outcome Measurements: Association between endoscopic features and presence of early neoplasia in autofluorescence-positive areas. Results: Autofluorescence intensity, proximity of gastric folds
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Esophageal Neoplasms
Biopsy
Population
Pilot Projects
Gastroenterology
Risk Assessment
Endoscopy, Gastrointestinal
Fluorescence
Diagnosis, Differential
Barrett Esophagus
Risk Factors
Internal medicine
medicine
Prevalence
Humans
Radiology, Nuclear Medicine and imaging
Single-Blind Method
Prospective Studies
Esophagus
Intestinal Mucosa
Prospective cohort study
education
Aged
Netherlands
education.field_of_study
medicine.diagnostic_test
business.industry
Esophageal disease
medicine.disease
Prognosis
Endoscopy
Autofluorescence
medicine.anatomical_structure
Barrett's esophagus
Referral center
Female
Radiology
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 10976779 and 00165107
- Volume :
- 70
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Gastrointestinal endoscopy
- Accession number :
- edsair.doi.dedup.....bc298464a2e224a6a94012050700bdb5