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Correlations between metabolic texture features, genetic heterogeneity, and mutation burden in patients with lung cancer
- Source :
- European journal of nuclear medicine and molecular imaging. 46(2)
- Publication Year :
- 2018
-
Abstract
- This study investigated the correlations between parameters of 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET) scan and indices of genetic properties, heterogeneity index (HI), and tumor mutation burden (TMB), in patients with lung cancer. We produced 106 PET indices for each tumor site that underwent genomic analysis in a total of 176 study subjects (age, 62.0 ± 10.0 y; males, 68.2%), comprising 101 adenocarcinoma (ADC), 29 squamous cell carcinoma (SQCC), and 46 small cell lung cancer (SCLC) patients. We then examined the correlations of the PET parameters with genetic properties of HI and TMB, according to pathology and tumor site. Comparisons between PET parameters and the genetic properties with false discovery rate (FDR) correction revealed that the surface standard uptake value (SUV) entropy of SUV statistics had a significant correlation with HI only in patients with SCLC who underwent a genetic test in lymph nodes (r = 0.592, p = 0.028), whereas PET parameters did not show a significant correlation with HI or TMB in patients with SCLC who underwent a genetic test in lung tissue. In patients with ADC and SQCC, there was no significant correlation between PET parameters and the genetic properties. Although SUVmax showed raw p values less than 0.05 in correlation with HI (r = 0.315, raw p = 0.048) and TMB (r = 0.206, raw p = 0.043) in ADC, and SUVpeak had a raw p value less than 0.05 in correlation with HI (r = 0.394, raw p = 0.046) in SQCC, these parameters were not significant when corrected by FDR. In this study, surface SUV entropy had a significant correlation with HI in SCLC. Regarding other PET parameters and tumors, no significant correlation with genetic parameters existed.
- Subjects :
- False discovery rate
Oncology
Adult
Male
medicine.medical_specialty
Lung Neoplasms
Standardized uptake value
030218 nuclear medicine & medical imaging
Correlation
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Internal medicine
Positron Emission Tomography Computed Tomography
medicine
Humans
Radiology, Nuclear Medicine and imaging
In patient
Lung cancer
Aged
Aged, 80 and over
medicine.diagnostic_test
business.industry
Genetic heterogeneity
General Medicine
Middle Aged
medicine.disease
Positron emission tomography
030220 oncology & carcinogenesis
Mutation
Adenocarcinoma
Female
business
Subjects
Details
- ISSN :
- 16197089
- Volume :
- 46
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- European journal of nuclear medicine and molecular imaging
- Accession number :
- edsair.doi.dedup.....bc1cc0404cbec027017851c92c5bd28d