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Amelioration of Airway Stenosis in Rabbit Models by Photodynamic Therapy with Talaporfin Sodium (NPe6)
- Source :
- Photochemistry and Photobiology. 85:714-718
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- It is difficult to treat patients with acquired airway stenosis, and the quality of life of such patients is therefore lowered. We have suggested the application of photodynamic therapy (PDT) as a new treatment for airway stenosis and have determined the efficacy of PDT in animal disease models using a second-generation photosensitizer with reduced photosensitivity. An airway stenosis rabbit model induced by scraping of the tracheal mucosa was administered NPe6 (5 mg kg(-1)), and the stenotic lesion was irradiated with 670 nm light emitted from a cylindrical diffuser tip at 60 J cm(-2) under bronchoscopic monitoring. PDT using NPe6 improved airway stenosis (P = 0.043) and respiratory stridor. A significant prolongation of survival time was seen in the PDT-treated animals compared to that in the untreated animals (P = 0.025) and 44% of the treated animals achieved long-term survival (>60 days). In conclusion, PDT using NPe6 is effective for improvement in airway stenosis.
- Subjects :
- Male
medicine.medical_specialty
Porphyrins
medicine.medical_treatment
Stridor
Urology
Photodynamic therapy
Constriction, Pathologic
Biochemistry
Constriction
medicine
Animals
Photosensitizer
Physical and Theoretical Chemistry
Respiratory system
business.industry
General Medicine
respiratory system
medicine.disease
Trachea
TALAPORFIN SODIUM
Disease Models, Animal
Stenosis
Photochemotherapy
Rabbits
medicine.symptom
Airway
business
Subjects
Details
- ISSN :
- 17511097 and 00318655
- Volume :
- 85
- Database :
- OpenAIRE
- Journal :
- Photochemistry and Photobiology
- Accession number :
- edsair.doi.dedup.....bc0cb45a45002bbad733c3404f241cec