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Uric acid: a potential biomarker of multiple sclerosis and of its disability
- Publication Year :
- 2015
-
Abstract
- Background: Uric acid (UA) is a strong natural scavenger of reactive oxygen and nitrogen species, with evidence of possible use in the treatment of animal models of multiple sclerosis (MS). Consequently, serum UA has gained much attention as a possible biomarker of MS. We aim to investigate differences in serum UA levels between MS subjects and controls and evaluate possible relationships of UA with MS clinical features. Methods: We recruited relapsing-remitting and secondary progressive MS subjects and healthy controls and measured their serum UA levels. We excluded subjects presenting concomitant conditions affecting UA levels. Results: MS subjects (n=362) and controls (n=181) were recruited by propensity score matching (PSM). Statistical analyses were corrected for age, gender, and renal function. MS subjects presented significantly lower serum UA levels than controls (analysis of variance, p=0.014, adjusted r2=0.3036). Linear regression analysis showed a relationship between UA levels and disease duration (p
- Subjects :
- Adult
Male
medicine.medical_specialty
Multiple Sclerosis
Adolescent
Clinical Biochemistry
Renal function
Gastroenterology
Expanded Disability Status Scale (EDSS)
Young Adult
chemistry.chemical_compound
uric acid
Internal medicine
Linear regression
Humans
Medicine
Disabled Persons
oxidant
scavenger
Aged
Retrospective Studies
Expanded Disability Status Scale
business.industry
Multiple sclerosis
Biochemistry (medical)
General Medicine
Middle Aged
medicine.disease
chemistry
Biochemistry
multiple sclerosi
Propensity score matching
Biomarker (medicine)
Uric acid
biomarker
urate
Female
Analysis of variance
business
Biomarkers
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....bc02b418bff7d3c44259cb0367bd8550