Back to Search
Start Over
Serum Osteocalcin and CTX-MMP Concentration in Young Exercising Thoroughbred Racehorses
- Source :
- Journal of Veterinary Medicine Series A. 52:114-120
- Publication Year :
- 2005
- Publisher :
- Wiley, 2005.
-
Abstract
- Summary Bone responds to exercise with changes in bone (re-)modelling, which might be monitored non-invasively with biochemical bone markers. The aim of this study was to evaluate the influence of exercise on serum osteocalcin and serum carboxy-terminal cross-linked telopeptide of type I collagen generated by matrix metalloproteinases (CTX-MMP) concentration in young racehorses. Seventy-one 2 to 4-year-old Thoroughbreds were included in this prospective infield study. Blood sampling was performed six times (i.e. six sampling cycles) during a 9-month period. Serum samples were analysed with commercial osteocalcin and CTX-MMP radioimmunoassays. Two-year-old racehorses had higher serum osteocalcin and CTX-MMP values than 3-year-old horses. Gender and training amplitude did not significantly influence serum osteocalcin and CTX-MMP values. Two-year-old horses showed an increase in osteocalcin values between cycles 2 and 3 and an increase in serum CTX-MMP values between cycles 1 and 2. Serum osteocalcin and CTX-MMP concentrations decreased between cycles 4 and 5, and 5 and 6. Three-year-old horses showed an increase in serum osteocalcin levels between cycles 3 and 4 and an increase in serum CTX-MMP concentrations between cycles 1 and 2, and 3 and 4. Serum osteocalcin levels decreased between cycles 5 and 6, whereas serum CTX-MMP levels decreased between cycles 4 and 5, and 5 and 6. Two- and three-year-old horses showed a decreased osteocalcin/CTX-MMP ratio between cycles 1 and 2. Moreover, 2-year-old horses showed an increase in the osteocalcin/CTX-MMP ratio between cycles 2 and 3. Sore shin formation did not significantly influence serum osteocalcin and CTX-MMP values. Serum osteocalcin and CTX-MMP are promising bone markers for monitoring exercise induced changes in equine bone metabolism.
- Subjects :
- Male
medicine.medical_specialty
Osteocalcin
Radioimmunoassay
Matrix metalloproteinase
Bone and Bones
Collagen Type I
Pathology and Forensic Medicine
Bone remodeling
N-terminal telopeptide
Physical Conditioning, Animal
Internal medicine
medicine
Animals
Horses
Prospective Studies
General Veterinary
biology
business.industry
Age Factors
Matrix Metalloproteinases
Endocrinology
biology.protein
Female
Collagen
Serum osteocalcin
Peptides
business
Type I collagen
Blood sampling
Subjects
Details
- ISSN :
- 14390442 and 0931184X
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Medicine Series A
- Accession number :
- edsair.doi.dedup.....bbfb665946fc9dee36758968dd948984