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Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells
- Source :
- Nature Communications, Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Most cancer vaccines are unsuccessful in eliciting clinically relevant effects. Without using exogenous antigens and adoptive cells, we show a concept of utilizing biologically reprogrammed cytomembranes of the fused cells (FCs) derived from dendritic cells (DCs) and cancer cells as tumor vaccines. The fusion of immunologically interrelated two types of cells results in strong expression of the whole tumor antigen complexes and the immunological co-stimulatory molecules on cytomembranes (FMs), allowing the nanoparticle-supported FM (NP@FM) to function like antigen presenting cells (APCs) for T cell immunoactivation. Moreover, tumor-antigen bearing NP@FM can be bio-recognized by DCs to induce DC-mediated T cell immunoactivation. The combination of these two immunoactivation pathways offers powerful antitumor immunoresponse. Through mimicking both APCs and cancer cells, this cytomembrane vaccine strategy can develop various vaccines toward multiple tumor types and provide chances for accommodating diverse functions originating from the supporters.<br />Cancer vaccines often fail to generate clinically relevant effects. Here, the authors generate a nanosized cytomembrane vaccine based on fusion between dendritic cells and cancer cells, and show them to activate anti-tumor immune responses via their antigen presenting and T-cell activating functions.
- Subjects :
- 0301 basic medicine
Science
T-Lymphocytes
T cell
medicine.medical_treatment
Transplantation, Heterologous
General Physics and Astronomy
02 engineering and technology
Biology
Lymphocyte Activation
Cancer Vaccines
Article
General Biochemistry, Genetics and Molecular Biology
Cell Fusion
Mice
03 medical and health sciences
Antigen
Antigens, Neoplasm
Nanoscience and technology
Cell Line, Tumor
medicine
Animals
lcsh:Science
Antigen-presenting cell
Cancer
Antigen Presentation
Mice, Inbred BALB C
Multidisciplinary
Cell fusion
Cell Membrane
Mammary Neoplasms, Experimental
Dendritic Cells
General Chemistry
Immunotherapy
021001 nanoscience & nanotechnology
Tumor antigen
030104 developmental biology
medicine.anatomical_structure
Cell culture
Cancer cell
Cancer research
Nanoparticles
lcsh:Q
Female
Transcriptome
0210 nano-technology
Subjects
Details
- ISSN :
- 20411723
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....bbf86611bd5a78729835628cd6569208