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The risk of thromboembolic events in kidney transplant patients
- Source :
- Kidney International. Supplement, 85, 1454-60, Kidney International. Supplement, 85, 6, pp. 1454-60
- Publication Year :
- 2014
-
Abstract
- Item does not contain fulltext Little is known about the risk of venous thrombosis following kidney transplant. To determine this we estimated the risk of thromboembolic events (TEs) in a cohort of consecutive patients who underwent kidney transplantation at a single tertiary care center over an 11-year period and calculated standardized incidence ratios (SIRs) for a first TE in kidney transplant recipients compared with the general population. We then performed a nested case-control study and compared patients with and without TEs to identify risk factors for thrombosis. Among 913 kidney transplant recipients (KTRs), 68 patients developed these events. The SIR for TEs in KTRs compared with the general population was 7.9 over the duration of follow-up. The risk was particularly higher in the first post-transplant year (SIR 26.1) but remained elevated afterward (SIR 5.2). Hospitalization, use of sirolimus, low hemoglobin level, and use of renin-angiotensin system inhibitors were independently associated with these events. When cases of TEs that occurred during hospitalization were excluded, the risk of these events remained elevated. The risk of TEs in KTRs was eightfold higher than in the general population but not fully explained by the increased risk associated with hospitalization. Our results underscore the important risk of thrombosis in patients who received a kidney transplant, making vigilance mandatory especially during hospitalization.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Population
Patient Readmission
Risk Assessment
Tertiary Care Centers
Young Adult
Risk Factors
Thromboembolism
Internal medicine
medicine
Humans
education
Kidney transplantation
Aged
Retrospective Studies
Sirolimus
education.field_of_study
business.industry
Quebec
Retrospective cohort study
Middle Aged
medicine.disease
Kidney Transplantation
Thrombosis
Surgery
Venous thrombosis
Treatment Outcome
Nephrology
Cohort
Female
Renal disorders Radboud Institute for Health Sciences [Radboudumc 11]
business
Risk assessment
Immunosuppressive Agents
medicine.drug
Subjects
Details
- ISSN :
- 21571724
- Volume :
- 85
- Database :
- OpenAIRE
- Journal :
- Kidney International. Supplement
- Accession number :
- edsair.doi.dedup.....bbec417f80d2bdac05c9195f78faa972