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Extracellular superoxide dismutase activity is affected by dietary zinc intake in nonhuman primate and rodent models
- Source :
- The American Journal of Clinical Nutrition. 61:1263-1267
- Publication Year :
- 1995
- Publisher :
- Elsevier BV, 1995.
-
Abstract
- Assessment of zinc nutriture is often compromised by the lack of reliable biomarkers. In the present study the effect of dietary zinc deprivation on plasma extracellular superoxide dismutase (EC SOD) activity was investigated in rat and rhesus macaque models. This enzyme, which contains both zinc and copper, is distinct from cytosolic copper-zinc SOD. Young, growing rats fed zinc-deficient diets (1.5 nmol Zn/g diet) were characterized by low plasma zinc concentrations and plasma EC SOD activities (16% and 56% of controls, respectively). Adolescent rhesus macaques fed diets that contained a marginal amount of zinc (30.6 nmol Zn/g diet) also had low plasma zinc concentrations and low EC SOD activities compared with controls fed diets containing 765 nmol Zn/g diet (75% and 40%, respectively). Enzyme activity was not affected after in vitro addition of zinc to plasma samples from control, restrict-fed, and zinc-deficient rats. Taken together, these data support the concept that plasma EC SOD activity can be a biomarker for zinc status. Am J Clin Nutr 1995 ;61 :1263-7.
- Subjects :
- Male
medicine.medical_specialty
Nutritional Status
Medicine (miscellaneous)
chemistry.chemical_element
Zinc
Models, Biological
Rats, Sprague-Dawley
Superoxide dismutase
Internal medicine
medicine
Extracellular
Animals
chemistry.chemical_classification
Nutrition and Dietetics
biology
Superoxide Dismutase
medicine.disease
Macaca mulatta
Enzyme assay
In vitro
Diet
Rats
Cytosol
Enzyme
Endocrinology
chemistry
Zinc deficiency
biology.protein
Female
Subjects
Details
- ISSN :
- 00029165
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- The American Journal of Clinical Nutrition
- Accession number :
- edsair.doi.dedup.....bbe889190dc961bb04bd1b83fa9d2b16