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Isolation and identification of a novel impurity of erythromycin A 9-oxime desosaminehydrazinium salt
- Source :
- The Journal of antibiotics. 58(8)
- Publication Year :
- 2005
-
Abstract
- In the manufacturing process for Biaxin® (clarithromycin), erythromycin-A oxime, an intermediate, is obtained in high yield, when erythromycin-A is treated with hydroxylamine/isopropyl alcohol in the presence of acetic acid. An unusual impurity, the desosamine hydrazinium salt, is generated in this step of the synthetic pathway, and has been isolated and characterized by using one and two-dimensional NMR spectroscopy in conjunction with MS and EDS.
- Subjects :
- Pharmacology
chemistry.chemical_classification
Magnetic Resonance Spectroscopy
Desosamine
Salt (chemistry)
Isopropyl alcohol
General Medicine
Nuclear magnetic resonance spectroscopy
Oxime
Erythromycin
chemistry.chemical_compound
Acetic acid
Hydroxylamine
Hydrazines
chemistry
Yield (chemistry)
Drug Discovery
Organic chemistry
Nuclear chemistry
Subjects
Details
- ISSN :
- 00218820
- Volume :
- 58
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- The Journal of antibiotics
- Accession number :
- edsair.doi.dedup.....bbe48261a7b1976d6a9703591dc3ab77