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Chronic obsessive-compulsive disorder: prognostic factors
- Source :
- Psychological Medicine, 48, 2213-2222, Psychological Medicine, 48(13), 2213-2222. Cambridge University Press, Psychological Medicine, 48(13), 2213-2222, Van Oudheusden, L J B, Eikelenboom, M, Van Megen, H J G M, Visser, H A D, Schruers, K, Hendriks, G J, Van Der Wee, N, Hoogendoorn, A W, Van Oppen, P & Van Balkom, A J L M 2018, ' Chronic obsessive-compulsive disorder : Prognostic factors ', Psychological Medicine, vol. 48, no. 13, pp. 2213-2222 . https://doi.org/10.1017/S0033291717003701, Psychological Medicine, 48, 13, pp. 2213-2222
- Publication Year :
- 2018
-
Abstract
- BackgroundThe course of illness in obsessive–compulsive disorder (OCD) varies significantly between patients. Little is known about factors predicting a chronic course of illness. The aim of this study is to identify factors involved in inducing and in maintaining chronicity in OCD.MethodsThe present study is embedded within the Netherlands Obsessive Compulsive Disorder Association (NOCDA) study, an ongoing multicenter naturalistic cohort study designed to identify predictors of long-term course and outcome in OCD. For this study, 270 subjects with a current diagnosis of OCD were included. Chronicity status at 2-year follow-up was regressed on a selection of baseline predictors related to OCD, to comorbidity and to stress and support.ResultsPsychotrauma [odds ratio (OR) 1.98, confidence interval (CI) 1.22–3.22,p= 0.006], recent negative life events (OR 1.42, CI 1.01–2.01,p= 0.043), and presence of a partner (OR 0.28, CI 0.09–0.85,p= 0.025) influenced the risk of becoming chronic. Longer illness duration (OR 1.46, CI 1.08–1.96,p= 0.013) and higher illness severity (OR 1.09, CI 1.03–1.16,p= 0.003) increased the risk of remaining chronic.ConclusionsExternal influences increase the risk of becoming chronic, whereas the factors involved in maintaining chronicity are illness-related. As the latter are potentially difficult to modify, treatment should be devoted to prevent chronicity from occurring in the first place. Therapeutic strategies aimed at alleviating stress and at boosting social support might aid in achieving this goal.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
SYMPTOMS
SAMPLE
PROSPECTIVE FOLLOW-UP
Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13]
INVENTORY
Comorbidity
Severity of Illness Index
03 medical and health sciences
Social support
0302 clinical medicine
All institutes and research themes of the Radboud University Medical Center
CLINICAL CHARACTERISTICS
Obsessive compulsive
Risk Factors
Internal medicine
medicine
Obsessive-compulsive disorder
Illness severity
Humans
PREDICTORS
Applied Psychology
SCALE
Netherlands
business.industry
chronicity
Course of illness
course of illness
Odds ratio
Middle Aged
medicine.disease
Confidence interval
030227 psychiatry
CHILDHOOD TRAUMA
INTERVIEW
Psychiatry and Mental health
Chronic Disease
RELIABILITY
Disease Progression
Female
business
030217 neurology & neurosurgery
Cohort study
Follow-Up Studies
Subjects
Details
- ISSN :
- 00332917
- Database :
- OpenAIRE
- Journal :
- Psychological Medicine, 48, 2213-2222, Psychological Medicine, 48(13), 2213-2222. Cambridge University Press, Psychological Medicine, 48(13), 2213-2222, Van Oudheusden, L J B, Eikelenboom, M, Van Megen, H J G M, Visser, H A D, Schruers, K, Hendriks, G J, Van Der Wee, N, Hoogendoorn, A W, Van Oppen, P & Van Balkom, A J L M 2018, ' Chronic obsessive-compulsive disorder : Prognostic factors ', Psychological Medicine, vol. 48, no. 13, pp. 2213-2222 . https://doi.org/10.1017/S0033291717003701, Psychological Medicine, 48, 13, pp. 2213-2222
- Accession number :
- edsair.doi.dedup.....bbe2f489a934934aa0385bfdec1ecf1a