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Ventilatory defects and treatable traits in very elderly patients

Authors :: João Gaspar-Marques
Nuno Neuparth
Paula Leiria Pinto
Teresa Palmeiro
Pedro Carreiro-Martins
Iolanda Caires
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
Source :: Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP, Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos), Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
Publication Year :: 2021
Publisher :: SAGE Publications, 2021.
Abstract: Funding: The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This study was supported by AstraZeneca – Projecto OLDER (CEDOC/2015/59) and Finnee Project (PTDC/CCI-BIO/29702/2017). Though the approach used to classify chronic respiratory diseases is changing to a treatable-traits (TT) approach, data regarding very elderly patients is lacking. The objectives of this study were to assess TT frequency in very elderly patients and to study the link between extrapulmonary TT and ventilatory defects. Individuals (≥75 years) residing in elderly care centres answered a standardised questionnaire, underwent spirometry, atopy and fractional exhaled nitric oxide assessments and had their blood pressure and peripheral pulse oximetry measured. Pulmonary, extrapulmonary and behavioural TT were evaluated. Outcome variables were an airflow limitation (post-bronchodilator z-score FEV1/FVC