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Labrenzbactin from a coral-associated bacterium Labrenzia sp

Authors :
Amit Raj Sharma
Agus Trianto
Tao Zhou
Enjuro Harunari
Yasuhiro Igarashi
Naoya Oku
Source :
The Journal of Antibiotics. 72:634-639
Publication Year :
2019
Publisher :
Springer Science and Business Media LLC, 2019.

Abstract

A new catecholate-containing siderophore, labrenzbactin (1), was isolated from the fermentation broth of a coral-associated bacterium Labrenzia sp. The structure and absolute configuration of 1 was determined by spectroscopic methods and Marfey’s analysis. Overall, 1 showed antimicrobial activity against Ralstonia solanacearum SUPP1541 and Micrococcus luteus ATCC9341 with MIC values of 25 and 50 µg ml−1, respectively, and cytotoxicity against P388 murine leukemia cells with an IC50 of 13 µM.

Details

ISSN :
18811469 and 00218820
Volume :
72
Database :
OpenAIRE
Journal :
The Journal of Antibiotics
Accession number :
edsair.doi.dedup.....bbdb203cc5a5260f9a40c656dfa7e9f1
Full Text :
https://doi.org/10.1038/s41429-019-0192-x