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Labrenzbactin from a coral-associated bacterium Labrenzia sp
- Source :
- The Journal of Antibiotics. 72:634-639
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- A new catecholate-containing siderophore, labrenzbactin (1), was isolated from the fermentation broth of a coral-associated bacterium Labrenzia sp. The structure and absolute configuration of 1 was determined by spectroscopic methods and Marfey’s analysis. Overall, 1 showed antimicrobial activity against Ralstonia solanacearum SUPP1541 and Micrococcus luteus ATCC9341 with MIC values of 25 and 50 µg ml−1, respectively, and cytotoxicity against P388 murine leukemia cells with an IC50 of 13 µM.
- Subjects :
- 0301 basic medicine
Siderophore
030106 microbiology
Catechols
Siderophores
Microbial Sensitivity Tests
Ralstonia
01 natural sciences
Microbiology
Mice
03 medical and health sciences
Drug Discovery
Animals
Cytotoxicity
Oxazoles
Alphaproteobacteria
Pharmacology
Ralstonia solanacearum
Antibiotics, Antineoplastic
Molecular Structure
biology
Leukemia P388
010405 organic chemistry
Chemistry
fungi
Absolute configuration
food and beverages
Anthozoa
biology.organism_classification
Antimicrobial
Anti-Bacterial Agents
0104 chemical sciences
Micrococcus luteus
Fermentation
bacteria
Drug Screening Assays, Antitumor
Bacteria
Subjects
Details
- ISSN :
- 18811469 and 00218820
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- The Journal of Antibiotics
- Accession number :
- edsair.doi.dedup.....bbdb203cc5a5260f9a40c656dfa7e9f1
- Full Text :
- https://doi.org/10.1038/s41429-019-0192-x