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Nanocarriers for the targeted treatment of ovarian cancers
- Source :
- Biomaterials, Biomaterials, Elsevier, 2013, 34, pp.1073-1101
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- Ovarian cancer is the leading cause of death from gynecological malignancies worldwide. Although the majority of tumors initially respond to standard treatments combining surgery and chemotherapy with platinum based chemotherapy, frequent recurrence and subsequent acquired chemoresistance are responsible for the therapeutic failure, leading to an overall 5 years survival rate of 30%. Considering the usual initial sensitivity of the ovarian tumors to chemotherapy, over the past decade efforts have been focused over the past decade to cure ovarian cancer using the currently available chemotherapeutic agents in various combinations, dosages, schedules (durations and/or routes of administration). However, with such a systemic chemotherapeutic approach, considerable limitations exist including toxicities to healthy tissues and low achievable drug concentrations at tumor sites. Considerable efforts are implemented to engineer systems capable of ferrying large doses of cytotoxic agents specifically into targeted malignant cells while sparing healthy cells. The purpose of the present review is to index the main targeted colloidal systems used for drug delivery to ovarian tumors. These nanocarriers will be analyzed by citing examples of their use in preclinical development.
- Subjects :
- Oncology
Drug
medicine.medical_specialty
Surface Properties
medicine.medical_treatment
media_common.quotation_subject
Biophysics
Molecular Conformation
Bioengineering
Antineoplastic Agents
Pharmacology
Biomaterials
03 medical and health sciences
0302 clinical medicine
Nanocapsules
Internal medicine
Materials Testing
medicine
Humans
Particle Size
Survival rate
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
Cause of death
media_common
Ovarian Neoplasms
0303 health sciences
Chemotherapy
business.industry
medicine.disease
3. Good health
Mechanics of Materials
030220 oncology & carcinogenesis
Delayed-Action Preparations
Drug delivery
Ceramics and Composites
Therapeutic failure
Female
Nanocarriers
business
Ovarian cancer
Crystallization
Subjects
Details
- Language :
- English
- ISSN :
- 01429612
- Database :
- OpenAIRE
- Journal :
- Biomaterials, Biomaterials, Elsevier, 2013, 34, pp.1073-1101
- Accession number :
- edsair.doi.dedup.....bbdb17f1d9737eb1c6d0b3a78283fd4e