Back to Search
Start Over
Piroxicam accelerates development of colitis in T-cell receptor α chain-deficient mice
- Source :
- European Journal of Pharmacology. 615:241-245
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- T-cell receptor alpha chain (TCR.alpha)-deficient mice spontaneously develop colitis that resembles human ulcerative colitis; however, the incidence varies among individuals and takes place lately in the life. We have demonstrated that piroxicam induces colitis in non-colitic TCR.alpha-deficient mice, but not wild-type mice, within 14 days. The histological features and cytokine profiles were similar to those seen in spontaneous colitis in TCR.alpha-deficient mice. Dexamethasone prevented piroxicam-induced colitis concurrent with the suppression of interleukin (IL)-1beta, IL-17, tumor necrosis factor alpha and interferon gamma. This modified model of colitis could be useful for the evaluation of potential therapeutics for ulcerative colitis.
- Subjects :
- Male
Receptors, Antigen, T-Cell, alpha-beta
medicine.medical_treatment
Interleukin-1beta
Piroxicam
Inflammatory bowel disease
Dexamethasone
Interferon-gamma
Mice
medicine
Animals
Interferon gamma
Colitis
Glucocorticoids
Mice, Knockout
Pharmacology
Tumor Necrosis Factor-alpha
business.industry
Anti-Inflammatory Agents, Non-Steroidal
Interleukin-17
Interleukin
medicine.disease
Ulcerative colitis
Mice, Inbred C57BL
Cytokine
Immunology
Colitis, Ulcerative
Interleukin 17
business
medicine.drug
Subjects
Details
- ISSN :
- 00142999
- Volume :
- 615
- Database :
- OpenAIRE
- Journal :
- European Journal of Pharmacology
- Accession number :
- edsair.doi.dedup.....bbd8f0c6d30f6c5329566e8be3944514