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Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX
- Source :
- Neurotoxicity research. 16(4)
- Publication Year :
- 2008
-
Abstract
- The toxic effect of organophosphates is attributed to irreversible inhibition of acetylcholinesterase (AChE; EC 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. Inhibition potency in vivo of one of the most toxic nerve agents--Russian VX (RVX;N,N-diethyl-2-[methyl-(2-methylpropoxy)phosphoryl]sulfanylethanamine) (1 x LD(50) dose administered intramuscularly, i.m.) was studied in rats. AChE in blood was inhibited by 50%, 3 min after i.m. RVX. Butylcholinesterase (BChE; EC 3.1.1.8) in plasma was inhibited less rapidly and only by 10-20%, 20 min after RVX. AChE and BChE activities in diaphragm were reduced only 35% and 15% at 30 min. While AChE and BChE activities were reduced only about 20% and 15%, respectively, the decline in activity was rapid, occurring within 3 min. These findings indicate that RVX most potently inhibits ChE outside the central nervous system.
- Subjects :
- Male
Time Factors
Aché
Diaphragm
Pharmacology
Toxicology
Lethal Dose 50
chemistry.chemical_compound
In vivo
medicine
Potency
Animals
Tissue Distribution
Rats, Wistar
Neurotransmitter
Butyrylcholinesterase
Nerve agent
Behavior, Animal
General Neuroscience
Brain
Organothiophosphorus Compounds
Acetylcholinesterase
language.human_language
Rats
chemistry
Liver
language
Acetylcholine
medicine.drug
Subjects
Details
- ISSN :
- 14763524
- Volume :
- 16
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Neurotoxicity research
- Accession number :
- edsair.doi.dedup.....bbd5b0d06a84b4d385bf9dad9eff0d10