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Retinal and Circulating miRNAs in Age-Related Macular Degeneration: An In vivo Animal and Human Study
- Source :
- Frontiers in Pharmacology
- Publication Year :
- 2017
- Publisher :
- Frontiers Media SA, 2017.
-
Abstract
- Age related macular degeneration (AMD) is the leading cause of blindness among people aged 50 and over. Retinal deposition of amyloid-β (Aβ) aggregates in AMD patients has suggested a potential link between AMD and Alzheimer's disease (AD). We have evaluated the differential retinal expression profile of miRNAs in a rat model of AMD elicited by Aβ. A serum profile of miRNAs in AMD patients has been also assessed using single TaqMan assay. Analysis of retina from rats intravitreally injected with Aβ revealed that miR-27a, miR-146a, and miR-155 were up-regulated in comparison to control rats. Seven miRNA (miR-9, miR-23a, miR-27a, miR-34a, miR-126, miR-146a, and miR-155) have been found to be dysregulated in serum of AMD patients in comparison to control group. Analysis of pathways has revealed that dysregulated miRNAs, both in the AMD animal model and in AMD patients, can target genes regulating pathways linked to neurodegeneration and inflammation, reinforcing the hypothesis that AMD is a protein misfolding disease similar to AD. In fact, miR-9, miR-23a, miR-27a, miR-34a, miR-146a, miR-155 have been found to be dysregulated both in AMD and AD. In conclusion, we suggest that miR-9, miR-23a, miR-27a, miR-34a, miR-146a, miR-155 represent potential biomarkers and new pharmacological targets for AMD.
- Subjects :
- 0301 basic medicine
retina
Pathology
medicine.medical_specialty
genetic structures
Amyloid beta
age related macular degeneration
Inflammation
Biology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
In vivo
microRNA
medicine
Pharmacology (medical)
age-related macular degeneration
Original Research
miRNA
Pharmacology
Retina
Neurodegeneration
Retinal
Alzheimer's disease
Macular degeneration
medicine.disease
eye diseases
amyloid beta
retinal diseases
030104 developmental biology
medicine.anatomical_structure
chemistry
Immunology
biology.protein
sense organs
medicine.symptom
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 16639812
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Frontiers in Pharmacology
- Accession number :
- edsair.doi.dedup.....bbca22a48c89bb5730637d5b07dca056