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Human placenta and trophoblasts simultaneously express three isoforms of atypical protein kinase-c
- Source :
- Placenta. 119:39-43
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Atypical protein kinase-c (aPKC) isoforms are important regulators of polarity and stem cell differentiation. There are three isoforms of aPKC: aPKC-ι, aPKC-ζ, and PKM-ζ. Recently, aPKC-ι was shown to regulate human trophoblast stem cell (TSC) differentiation. Compensation by remaining isoforms when a single aPKC isoform is lost can occur, but the expression pattern of aPKC-ζ in placenta is unknown. Here we show that aPKC-ι, aPKC-ζ and a new isoform, aPKC-ζ III, are expressed in trophoblasts. Therefore, studies examining the role of aPKC isoforms that control for potential compensation between aPKC isoforms are necessary to understand aPKC-mediated regulation of TSC differentiation.
Details
- ISSN :
- 01434004
- Volume :
- 119
- Database :
- OpenAIRE
- Journal :
- Placenta
- Accession number :
- edsair.doi.dedup.....bbc733f47d1167f6f993f74d78928959