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Prognostic value of PET/CT with (18)F-fluoroazomycin arabinoside for patients with head and neck squamous cell carcinomas receiving chemoradiotherapy
- Source :
- Annals of nuclear medicine. 30(3):217-224
- Publication Year :
- 2015
- Publisher :
- Springer Japan, 2015.
-
Abstract
- The prognostic value of positron emission tomography/computed tomography (PET/CT) with 18F-fluoroazomycin arabinoside (FAZA) was evaluated in patients with head and neck squamous cell carcinoma (HNSCC) who underwent chemoradiotherapy (CRT). Twenty-nine patients with head and neck cancer underwent FAZA PET/CT before treatment. Data acquisition started 2 h after FAZA administration. In 26 patients with squamous cell carcinoma, FAZA uptakes by the primary lesions (tumor–muscle ratio in primary lesion: Pr T/M) and by the lymph node metastases (tumor–muscle ratio in lymph node metastasis) were compared with various clinical parameters. For the HNSCC patients who completed CRT protocol (n = 23), those who experienced disease progression were compared with those who did not experience disease progression with respect to the clinical and PET parameters. The prognostic values of the clinical and PET parameters were then evaluated with regard to progression-free survival (PFS). Pr T/M positively correlated with the lesion’s maximum diameter, and it was significantly higher in stage IV lesions compared with stage I–III lesions. No significant differences were observed between the patients who experienced disease progression and those who did not, with respect to the clinical parameters. The average Pr T/M tended to be higher in patients with disease progression, although the differences were not statistically significant (p = 0.086). Kaplan–Meier analysis with log-rank tests indicated that Pr T/M was an only significant predictor of PFS among PET and clinical parameters evaluated (p = 0.010). FAZA uptake by the primary lesion was a significant prognostic indicator in HNSCC patients undergoing CRT. Hence, FAZA PET/CT may provide useful information in the management of HNSCC patients treated with CRT. Registration number of clinical trial’s registry: UMIN000003440.
- Subjects :
- Male
030218 nuclear medicine & medical imaging
Lesion
03 medical and health sciences
0302 clinical medicine
Positron Emission Tomography Computed Tomography
medicine
Humans
Radiology, Nuclear Medicine and imaging
Stage (cooking)
Lymph node
PET-CT
medicine.diagnostic_test
Squamous Cell Carcinoma of Head and Neck
business.industry
Head and neck cancer
Chemoradiotherapy
General Medicine
Middle Aged
Prognosis
medicine.disease
Head and neck squamous-cell carcinoma
stomatognathic diseases
medicine.anatomical_structure
Head and Neck Neoplasms
Nitroimidazoles
Positron emission tomography
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Female
medicine.symptom
Nuclear medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 09147187
- Volume :
- 30
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Annals of nuclear medicine
- Accession number :
- edsair.doi.dedup.....bbc4d98c2ffa92bd9af7d7cf49ee82c0