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The role of BMP4 signaling in trophoblast emergence from pluripotency
- Source :
- Cellular and molecular life sciences : CMLS, vol 79, iss 8, Cell Mol Life Sci
- Publication Year :
- 2022
- Publisher :
- eScholarship, University of California, 2022.
-
Abstract
- The Bone Morphogenetic Protein (BMP) signaling pathway has established roles in early embryonic morphogenesis, particularly in the epiblast. More recently, however, it has also been implicated in development of extraembryonic lineages, including trophectoderm (TE), in both mouse and human. In this review, we will provide an overview of this signaling pathway, with a focus on BMP4, and its role in emergence and development of TE in both early mouse and human embryogenesis. Subsequently, we will build on these in vivo data and discuss the utility of BMP4-based protocols for in vitro conversion of primed vs. naïve pluripotent stem cells (PSC) into trophoblast, and specifically into trophoblast stem cells (TSC). PSC-derived TSC could provide an abundant, reproducible, and ethically acceptable source of cells for modeling placental development.
- Subjects :
- Pluripotent Stem Cells
Biochemistry & Molecular Biology
Physiology
Placenta
Trophoblast stem cells
1.1 Normal biological development and functioning
Clinical Sciences
Bone Morphogenetic Protein 4
Regenerative Medicine
Article
Cellular and Molecular Neuroscience
Mice
Pregnancy
Underpinning research
Animals
Humans
Naive pluripotency
Molecular Biology
Cytotrophoblast
Pharmacology
Pediatric
Epiblast
Bone Morphogenetic Protein
Cell Differentiation
Cell Biology
Stem Cell Research
Naïve pluripotency
Trophoblasts
Primed pluripotency
Molecular Medicine
Trophectoderm
Female
Inner cell mass
Stem Cell Research - Nonembryonic - Non-Human
Biochemistry and Cell Biology
Signal Transduction
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Cellular and molecular life sciences : CMLS, vol 79, iss 8, Cell Mol Life Sci
- Accession number :
- edsair.doi.dedup.....bbc12644b73a9e5a3c7d669396ca1bc5