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A multivariate neuroimaging biomarker of individual outcome to transcranial magnetic stimulation in depression
- Source :
- Hum Brain Mapp
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- The neurobiology of major depressive disorder (MDD) remains incompletely understood, and many individuals fail to respond to standard treatments. Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) has emerged as a promising antidepressant therapy. However, the heterogeneity of response underscores a pressing need for biomarkers of treatment outcome. We acquired resting state functional magnetic resonance imaging (rsfMRI) data in 47 MDD individuals prior to 5–8 weeks of rTMS treatment targeted using the F3 beam approach and in 29 healthy comparison subjects. The caudate, prefrontal cortex, and thalamus showed significantly lower blood oxygenation level‐dependent (BOLD) signal power in MDD individuals at baseline. Critically, individuals who responded best to treatment were associated with lower pre‐treatment BOLD power in these regions. Additionally, functional connectivity (FC) in the default mode and affective networks was associated with treatment response. We leveraged these findings to train support vector machines (SVMs) to predict individual treatment responses, based on learned patterns of baseline FC, BOLD signal power and clinical features. Treatment response (responder vs. nonresponder) was predicted with 85–95% accuracy. Reduction in symptoms was predicted to within a mean error of ±16% (r = .68, p
- Subjects :
- Male
Support Vector Machine
medicine.medical_treatment
Brain mapping
0302 clinical medicine
Prospective Studies
Prefrontal cortex
Research Articles
Default mode network
Brain Mapping
Radiological and Ultrasound Technology
medicine.diagnostic_test
05 social sciences
Middle Aged
Magnetic Resonance Imaging
Transcranial Magnetic Stimulation
3. Good health
Treatment Outcome
medicine.anatomical_structure
Neurology
Major depressive disorder
Female
Anatomy
Adult
medicine.medical_specialty
Neuroimaging
behavioral disciplines and activities
050105 experimental psychology
Young Adult
03 medical and health sciences
Physical medicine and rehabilitation
Predictive Value of Tests
medicine
Humans
0501 psychology and cognitive sciences
Radiology, Nuclear Medicine and imaging
Aged
Depressive Disorder, Major
business.industry
Magnetic resonance imaging
medicine.disease
Oxygen
Transcranial magnetic stimulation
Dorsolateral prefrontal cortex
Affect
Neurology (clinical)
Nerve Net
business
Biomarkers
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10970193 and 10659471
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Human Brain Mapping
- Accession number :
- edsair.doi.dedup.....bbbeb3b3a1f38fa04d2f3f528eb0be91