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Comparison of multi echo T2 relaxation and steady state approaches for myelin imaging in the central nervous system
- Source :
- Scientific Reports, Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- The traditional approach for measuring myelin-associated water with quantitative magnetic resonance imaging (MRI) uses multi-echo T2 relaxation data to calculate the myelin water fraction (MWF). A fundamentally different approach, abbreviated “mcDESPOT”, uses a more efficient steady-state acquisition to generate an equivalent metric (fM). Although previous studies have demonstrated inherent instability and bias in the complex mcDESPOT analysis procedure, fM has often been used as a surrogate for MWF. We produced and compared multivariate atlases of MWF and fM in healthy human brain and cervical spinal cord (available online) and compared their ability to detect multiple sclerosis pathology. A significant bias was found in all regions (p –5), albeit reversed for spinal cord (fM-MWF = − 3.4%) compared to brain (+ 6.2%). MWF and fM followed an approximately linear relationship for regions with MWF ~ 10%, the relationship broke down and fM no longer increased in tandem with MWF. For multiple sclerosis patients, MWF and fM Z score maps showed overlapping areas of low Z score and similar trends between patients and brain regions, although those of fM generally had greater spatial extent and magnitude of severity. These results will guide future choice of myelin-sensitive quantitative MRI and improve interpretation of studies using either myelin imaging approach.
- Subjects :
- Adult
Male
Multiple Sclerosis
Steady state (electronics)
Science
Myelin biology and repair
Central nervous system
Article
030218 nuclear medicine & medical imaging
03 medical and health sciences
Myelin
0302 clinical medicine
Nuclear magnetic resonance
medicine
Humans
Myelin Sheath
Aged
Multidisciplinary
business.industry
Multiple sclerosis
Brain
Cervical Cord
Human brain
Middle Aged
medicine.disease
Magnetic Resonance Imaging
medicine.anatomical_structure
T2 relaxation
Medicine
Female
Spatial extent
business
Biomarkers
030217 neurology & neurosurgery
Multi echo
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....bbbbc90022460951ecbdbd21470580b8