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Detection of incipient tumours by screening of circulating plasma DNA: hype or hope?
- Source :
- Acta clinica Belgica, 75(1), 9-18. Taylor and Francis Ltd.
- Publication Year :
- 2019
-
Abstract
- Background: The last half-decade has been marked by a rapid expansion of research efforts in the field of so-called liquid biopsies, thereby investigating the potential of blood-derived cell-free tumour DNA (ctDNA) markers for application in clinical oncological management. The analysis of cfDNA appears to be particularly attractive for therapy monitoring purposes, while in terms of early cancer diagnosis and screening the potentials are just starting to be explored. Challenges, both of biological and technical nature, need to be addressed. One such challenge is to overcome the low levels of ctDNA in the circulation, intrinsic to many early-stage cancers. Methods: Here, we give an overview of the features of ctDNA and the approaches that are currently being applied with the ultimate aim to detect tumours in a presymptomatic stage. Conclusion: Although many studies report encouraging results, further technical development and larger studies are warranted before application of ctDNA analysis may find its place in clinic. ispartof: ACTA CLINICA BELGICA vol:75 issue:1 pages:9-18 ispartof: location:England status: published
- Subjects :
- Oncology
FREE NUCLEIC-ACIDS
medicine.medical_specialty
BLOOD
Early cancer
DNA Copy Number Variations
Cancer detection
Circulating Tumor DNA
Epigenesis, Genetic
cell-free DNA
MUTATION DETECTION
03 medical and health sciences
Medicine, General & Internal
0302 clinical medicine
General & Internal Medicine
Internal medicine
Neoplasms
Biomarkers, Tumor
Medicine
Humans
030212 general & internal medicine
Liquid biopsy
Early Detection of Cancer
METHYLATION PATTERNS
Science & Technology
business.industry
Rapid expansion
Plasma dna
INCIDENTAL DETECTION
Liquid Biopsy
CLONAL HEMATOPOIESIS
General Medicine
NONINVASIVE DETECTION
CANCER
Biomarker (cell)
cancer detection
Cell-free fetal DNA
TISSUE
030220 oncology & carcinogenesis
Mutation
biomarker
Therapy monitoring
business
Life Sciences & Biomedicine
Subjects
Details
- ISSN :
- 22953337 and 17843286
- Volume :
- 75
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Acta clinica Belgica
- Accession number :
- edsair.doi.dedup.....bbb8d44db0d74e8ba91f902efbf7ca02