Back to Search
Start Over
Factors affecting R0 resection of colorectal cancer with synchronous peritoneal metastases: a multicenter prospective observational study by the Japanese Society for Cancer of the Colon and Rectum
- Source :
- International Journal of Clinical Oncology. 25:330-337
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- In Japan, R0 resection has been recommended for colorectal cancer patients with peritoneal metastases confined to the adjacent peritoneum and those with a few metastases to the distant peritoneum. R0 resection for M1c disease has drawn attention in Western countries and is currently considered an acceptable therapeutic option in the US National Comprehensive Cancer Network guidelines. However, clinical factors that affect the choice of R0 resection are unknown. This multicenter, prospective, observational study was conducted by the Japanese Society for Cancer of the Colon and Rectum. Colorectal cancer patients with synchronous peritoneal metastases were enrolled at 28 institutions in Japan from October 2012 to December 2016. To determine factors affecting R0 resection and R1 resection with intended R0 resection, stepwise logistic regression analyses were performed on clinical factors including age, sex, performance status (PS), body mass index, peritoneal cancer index (PCI) score, presence of ascites, presence of distant metastases, and primary tumor site. R0/R1 resection was performed in 36 (31/5; 25%) of 146 patients. No distant metastases [odds ratio (OR) 52.9; 95% confidence interval (CI) 13.3–210.1; p
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Colorectal cancer
Rectum
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Japan
Internal medicine
Humans
Medicine
Prospective Studies
Peritoneal Neoplasms
Aged
Aged, 80 and over
Performance status
business.industry
Cancer
Hematology
General Medicine
Odds ratio
Middle Aged
Prognosis
medicine.disease
Primary tumor
Survival Rate
Logistic Models
030104 developmental biology
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Conventional PCI
Peritoneal Cancer Index
Female
Surgery
Peritoneum
Colorectal Neoplasms
business
Subjects
Details
- ISSN :
- 14377772 and 13419625
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- International Journal of Clinical Oncology
- Accession number :
- edsair.doi.dedup.....bbb776137a65decf326f3a16b802356b