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Pharmacological intervention studies using mouse models of the inflammatory bowel diseases
- Source :
- Inflammatory Bowel Diseases. 17:1229-1245
- Publication Year :
- 2011
- Publisher :
- Oxford University Press (OUP), 2011.
-
Abstract
- Most therapeutic agents used in clinical practice today were originally developed and tested in animal models so that drug toxicity and safety, dose-responses and efficacy could be determined. Retrospective analyses of preclinical intervention studies using animal models of different diseases demonstrate that only a small percentage of the interventions reporting promising effects translate to clinical efficacy. The failure to translate therapeutic efficacy from bench to bedside may be due, in part, to shortcomings in the design of the clinical studies; however, it is becoming clear that much of the problem resides within the preclinical studies. One potential strategy for improving our ability to identify new therapeutics that may have a reasonable chance of success in well-controlled clinical trials is to identify the most relevant mouse models IBD and pharmacologic strategies that most closely mimic the clinical situation. To begin this process, we present a critical evaluation of the different mouse models and pharmacological approaches that may be used in intervention studies as well as discuss emerging issues related to study design and data interpretation of preclinical studies.
- Subjects :
- Drug
medicine.medical_specialty
business.industry
media_common.quotation_subject
Drug Evaluation, Preclinical
Gastroenterology
Psychological intervention
MEDLINE
Inflammatory Bowel Diseases
Pharmacology
Intervention studies
Preclinical data
Article
Clinical trial
Disease Models, Animal
Mice
Drug Design
medicine
Animals
Immunology and Allergy
Clinical efficacy
Intensive care medicine
business
media_common
Subjects
Details
- ISSN :
- 10780998
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Inflammatory Bowel Diseases
- Accession number :
- edsair.doi.dedup.....bbb09c6250828d88f67e30baad7f6a0d