Start Over

Shaping the mouse heart tube from the second heart field epithelium

Authors :: Paul Palmquist-Gomes
Sigolène M Meilhac
Morphogenèse du cœur - Heart morphogenesis (Imagine - Institut Pasteur U1163)
Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)
Work in the Meilhac laboratory is supported by core funding from the Institut Pasteur and by state funding from the Agence Nationale de la Recherche under the ‘Investissements d’avenir’ program (ANR-10-IAHU-01). PPG is recipient of a Pasteur-Roux-Cantarini fellowship from the Institut Pasteur.
ANR-10-IAHU-0001,Imagine,Institut Hospitalo-Universitaire Imagine(2010)
Source :: Current Opinion in Genetics and Development, Current Opinion in Genetics and Development, 2022, 73, pp.101896. ⟨10.1016/j.gde.2021.101896⟩
Publication Year :: 2022
Publisher :: Elsevier BV, 2022.
Abstract: International audience; As other tubular organs, the embryonic heart develops from an epithelial sheet of cells, referred to as the heart field. The second heart field, which lies in the dorsal pericardial wall, constitutes a transient cell reservoir, integrating patterning and polarity cues. Conditional mutants have shown that impairment of the epithelial architecture of the second heart field is associated with congenital heart defects. Here, taking the mouse as a model, we review the epithelial properties of the second heart field and how they are modulated upon cardiomyocyte differentiation. Compared to other cases of tubulogenesis, the cellular dynamics in the second heart field are only beginning to be revealed. A challenge for the future will be to unravel key physical forces driving heart tube morphogenesis.