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Maternal and neonatal risk factors for neonatal respiratory distress syndrome in term neonates in Cyprus: a prospective case–control study
- Source :
- Italian Journal of Pediatrics, Italian Journal of Pediatrics, Vol 47, Iss 1, Pp 1-9 (2021)
- Publication Year :
- 2021
- Publisher :
- BioMed Central, 2021.
-
Abstract
- Background Neonatal respiratory distress syndrome (NRDS) is strongly associated with premature birth, but it can also affect term neonates. Unlike the extent of research in preterm neonates, risk factors associated with incidence and severity of NRDS in term neonates are not well studied. In this study, we examined the association of maternal and neonatal risk factors with the incidence and severity of NRDS in term neonates admitted to Neonatal Intensive Care Unit (NICU) in Cyprus. Methods In a prospective, case-control design we recruited term neonates with NRDS and non-NRDS admitted to the NICU of Archbishop Makarios III hospital, the only neonatal tertiary centre in Cyprus, between April 2017–October 2018. Clinical data were obtained from patients’ files. We used univariate and multivariate logistic and linear regression models to analyse binary and continuous outcomes respectively. Results During the 18-month study period, 134 term neonates admitted to NICU were recruited, 55 (41%) with NRDS diagnosis and 79 with non-NRDS as controls. In multivariate adjusted analysis, male gender (OR: 4.35, 95% CI: 1.03–18.39, p = 0.045) and elective caesarean section (OR: 11.92, 95% CI: 1.80–78.95, p = 0.01) were identified as independent predictors of NRDS. Among neonates with NRDS, early-onset infection tended to be associated with increased administration of surfactant (β:0.75, 95% CI: − 0.02-1.52, p = 0.055). Incidence of pulmonary hypertension or systemic hypotension were associated with longer duration of parenteral nutrition (pulmonary hypertension: 11Vs 5 days, p p = 0.01) and higher rate of blood transfusion (pulmonary hypertension: 100% Vs 67%, p = 0.045, systemic hypotension: 85% Vs 55%, p = 0.013). Conclusions This study highlights the role of elective caesarean section and male gender as independent risk factors for NRDS in term neonates. Certain therapeutic interventions are associated with complications during the course of disease. These findings can inform the development of evidence-based recommendations for improved perinatal care.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Neonatal respiratory distress syndrome
Blood transfusion
Neonatal intensive care unit
Term Birth
medicine.medical_treatment
RJ1-570
Neonatal risk factors
03 medical and health sciences
0302 clinical medicine
Sex Factors
Pregnancy
Risk Factors
medicine
Humans
Caesarean section
030212 general & internal medicine
Prospective Studies
Respiratory Distress Syndrome, Newborn
030219 obstetrics & reproductive medicine
business.industry
Cesarean Section
Incidence (epidemiology)
Research
Case-control study
Infant, Newborn
Pulmonary Surfactants
Maternal risk factors
medicine.disease
Pulmonary hypertension
Premature birth
Case-Control Studies
Cyprus
Female
business
Subjects
Details
- Language :
- English
- ISSN :
- 18247288
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Italian Journal of Pediatrics
- Accession number :
- edsair.doi.dedup.....bb9b9b3da7ae8b1066807cd2277aa754