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Effect of E5510 on anastomotic intimal hyperplasia and platelet aggregation in dogs
- Source :
- Journal of cardiovascular pharmacology. 27(6)
- Publication Year :
- 1996
-
Abstract
- We examined the effect of an antiplatelet agent, E5510, which inhibits both platelet aggregation and release of platelet-derived growth factor (PDGF), on anastomotic intimal hyperplasia and platelet aggregation. Twenty Beagle dogs underwent infrarenal aortic reconstruction with an expanded polytetrafluoroethylene (ePTFE) graft 5 mm in diameter and 3 cm long. The dogs were divided into three groups: placebo (control group, 7 dogs), E5510 1 mg/day (1-mg group, 6 dogs), and E5510 4 mg/day (4-mg group, 7 dogs). E5510 was administered orally 2 h before operation and once daily for 3 months after operation. Grafts were harvested 3 months after operation. All 13 grafts in the treated groups remained patent without evidence of intimal hyperplasia, whereas only 4 of 7 grafts (57%) remained patent in the control group, including 1 graft with > 50% stenosis. Three occluded grafts showed severe intimal hyperplasia at the anastomoses. The platelet aggregation ratio (PAR) with collagen (100 micrograms/ml) before drug administration at 3 months in the 4-mg group was significantly lower than that in the control and 1-mg groups. PAR after drug administration at 3 months in the 1- and 4-mg groups was significantly lower than that in the control group. Intimal thickness at the distal anastomosis was 817 +/- 190 microns in the control group, 240 +/- 80 microns in the 1-mg group, and 197 +/- 28 microns in the 4-mg group. Intimal thickness in the control group was significantly greater than that in the 1- and 4-mg groups. Smooth muscle cell (SMC) values in the intima at the distal anastomosis were 65.6 +/- 4.4% extinction (%E) in the control group, 47.6 +/- 3.4%E in the 1-mg group, and 51.3 +/- 3.5%E in the 4-mg group. SMC value in the control group was significantly greater than that in the 1- and 4-mg groups. E5510 inhibited PAR and reduced the degree of anastomotic intimal hyperplasia.
- Subjects :
- Blood Platelets
medicine.medical_specialty
Intimal hyperplasia
Urology
Anastomosis
Beagle
Fatty Acids, Monounsaturated
Dogs
medicine
Animals
Platelet
Aorta
Pharmacology
Hyperplasia
biology
business.industry
Fissipedia
Anastomosis, Surgical
medicine.disease
biology.organism_classification
Surgery
Stenosis
medicine.anatomical_structure
Female
Cardiology and Cardiovascular Medicine
business
Tunica Intima
Platelet Aggregation Inhibitors
Blood vessel
Subjects
Details
- ISSN :
- 01602446
- Volume :
- 27
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of cardiovascular pharmacology
- Accession number :
- edsair.doi.dedup.....bb970672f79c3402d1c5b70cbd394bd6