The ABL kinase inhibitor STI571 does not affect survival of hematopoietic cells after ionizing radiation

The c-Abl gene encodes a widely expressed tyrosine kinase that is important for development, particularly of the nervous system.[1][1] But the signaling pathways that employ c-Abl in normal cells are not well defined. Abl protein is located in both the nucleus and the cytoplasm, and recent studies