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Correction: A catalog of potential putative functional variants in psoriasis genome-wide association regions
- Source :
- PLoS ONE, PLoS ONE, Vol 13, Iss 6, p e0199322 (2018)
- Publication Year :
- 2018
-
Abstract
- Psoriasis is a common inflammatory skin disease, with considerable genetic contribution. Genome-wide association studies have successfully identified a number of genomic regions for the risk of psoriasis. However, it is challenging to pinpoint the functional causal variants and then further decipher the genetic mechanisms underlying each region. In order to prioritize potential functional causal variants within psoriasis susceptibility regions, we integrated the genetic association findings and functional genomic data publicly available, i.e. histone modifications in relevant immune cells. We characterized a pervasive enrichment pattern of psoriasis variants in five core histone marks across immune cells/tissues. We discovered that genetic alleles within psoriasis association regions might influence gene expression levels through significantly affecting the binding affinities of 17 transcription factors. We established a catalog of 654 potential functional causal variants for psoriasis and suggested that they significantly overlapped with causal variants for autoimmune diseases. We identified potential causal variant rs79824801 overlay with the peaks of five histone marks in primary CD4+ T cells. Its alternative allele affected the binding affinity of transcription factor IKZF1. This study highlights the complex genetic architecture and complicated mechanisms for psoriasis. The findings will inform the functional experiment design for psoriasis.
- Subjects :
- Immune Cells
Immunology
lcsh:Medicine
Gene Expression
Genome-wide association study
Computational biology
Biology
Biochemistry
Autoimmune Diseases
Histones
White Blood Cells
Animal Cells
Psoriasis
DNA-binding proteins
medicine
Medicine and Health Sciences
Genome-Wide Association Studies
Genetics
Gene Regulation
T Helper Cells
lcsh:Science
Multidisciplinary
Blood Cells
lcsh:R
Biology and Life Sciences
Computational Biology
Proteins
Human Genetics
Genomics
Cell Biology
medicine.disease
Genome Analysis
Functional Genomics
Regulatory Proteins
Genetics of Disease
lcsh:Q
Clinical Immunology
Clinical Medicine
Cellular Types
Research Article
Transcription Factors
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 13
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....bb77de2e29ff15fef59ee9c47bc1ad93