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Impact of Routine Cryptococcal Antigen Screening and Targeted Preemptive Fluconazole Therapy in Antiretroviral-naive Human Immunodeficiency Virus–infected Adults With CD4 Cell Counts <100/μL: A Systematic Review and Meta-analysis

Authors :
Graeme Meintjes
Joseph N Jarvis
Thomas S. Harrison
Elvis Temfack
René Spijker
Olivier Lortholary
Jean Joel Bigna
Françoise Dromer
Jérémie F. Cohen
Henry Luma
Hôpital Général de Douala
Mycologie moléculaire - Molecular Mycology
Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)
Centre Pasteur du Cameroun
Réseau International des Instituts Pasteur (RIIP)
University Medical Center [Utrecht]
University of Cape Town
London School of Hygiene and Tropical Medicine (LSHTM)
St George‘s, University of London
Botswana Harvard AIDS Institute Partnership
Université Paris Descartes - Paris 5 (UPD5)
Centre d'infectiologie Necker-Pasteur [CHU Necker]
CHU Necker - Enfants Malades [AP-HP]
This study was supported by the French National Agency for HIV and Hepatitis Research (to E. T.’ s PhD program
predoctoral bursary No. 33/CSS6/AO 2013-1). J. N. J. has received grants from Gilead.T. H. reports grants from Gilead Sciences, personal fees from Pfizer, Gilead Sciences, and Viamet, and nonfinancial support from Immuno-Mycologics.
Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
St George's, University of London
Institut Pasteur [Paris] (IP)-CHU Necker - Enfants Malades [AP-HP]
Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris]
Institut Pasteur [Paris]-CHU Necker - Enfants Malades [AP-HP]
Source :
Clinical Infectious Diseases, Clinical Infectious Diseases, Oxford University Press (OUP), 2019, 68 (4), pp.688-698. ⟨10.1093/cid/ciy567⟩, Clinical Infectious Diseases, 2019, 68 (4), pp.688-698. ⟨10.1093/cid/ciy567⟩
Publication Year :
2019
Publisher :
HAL CCSD, 2019.

Abstract

International audience; Cryptococcal antigen (CrAg) screening and targeted preemptive fluconazole in antiretroviral-naive human immunodeficiency virus-infected adults with CD4 cell counts

Subjects

Subjects :
0301 basic medicine
Microbiology (medical)
Adult
Male
medicine.medical_specialty
Antifungal Agents
030106 microbiology
HIV Infections
Meningitis, Cryptococcal
Asymptomatic
Chemoprevention
03 medical and health sciences
Young Adult
preemptive
0302 clinical medicine
Internal medicine
fluconazole
Antiretroviral naive
Prevalence
Medicine
Humans
030212 general & internal medicine
Young adult
[SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
Aged
Aged, 80 and over
medicine.diagnostic_test
business.industry
Lumbar puncture
Incidence (epidemiology)
Incidence
screening
cryptococcal antigen
meningitis
lateral flow assay
Middle Aged
medicine.disease
3. Good health
CD4 Lymphocyte Count
latex agglutination
Infectious Diseases
Meta-analysis
Female
medicine.symptom
business
Meningitis
Fluconazole
medicine.drug

Details

Language :
English
ISSN :
10584838 and 15376591
Database :
OpenAIRE
Journal :
Clinical Infectious Diseases, Clinical Infectious Diseases, Oxford University Press (OUP), 2019, 68 (4), pp.688-698. ⟨10.1093/cid/ciy567⟩, Clinical Infectious Diseases, 2019, 68 (4), pp.688-698. ⟨10.1093/cid/ciy567⟩
Accession number :
edsair.doi.dedup.....bb5a734143337be5e0d718c269b30162
Full Text :
https://doi.org/10.1093/cid/ciy567⟩
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