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The intersection between immunotherapy and laser interstitial thermal therapy: a multipronged future of neuro-oncology
- Source :
- International Journal of Hyperthermia, Vol 37, Iss 2, Pp 27-34 (2020)
- Publication Year :
- 2020
-
Abstract
- The rise of immunotherapy (IT) in oncological treatment has greatly improved outcomes in a number of disease states. However, its use in tumors of the central nervous system (CNS) remains limited for multiple reasons related to the unique immunologic tumor microenvironment. As such, it is valuable to consider the intersection of IT with additional treatment methods that may improve access to the CNS and effectiveness of existing IT modalities. One such combination is the pairing of IT with localized hyperthermia (HT) generated through technologies such as laser interstitial thermal therapy (LITT). The wide-ranging immunomodulatory effects of localized and whole-body HT have been investigated for some time. Hyperthermia has demonstrated immunostimulatory effects at the level of tumor cells, immune cells, and the broader environment governing potential immune surveillance. A thorough understanding of these effects as well as the current and upcoming investigations of such in combination with IT is important in considering the future directions of neuro-oncology.
- Subjects :
- Hyperthermia
Cancer Research
lcsh:Medical technology
Physiology
Neuro oncology
medicine.medical_treatment
Disease
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Immune system
Laser Interstitial Thermal Therapy
Physiology (medical)
Tumor Microenvironment
cancer
Medicine
Humans
neurosurgery
Tumor microenvironment
business.industry
Brain Neoplasms
Lasers
Cancer
Immunotherapy
Hyperthermia, Induced
hyperthermia
medicine.disease
laser interstitial thermal therapy (litt)
lcsh:R855-855.5
030220 oncology & carcinogenesis
Cancer research
Laser Therapy
business
neuro-oncology
Subjects
Details
- ISSN :
- 14645157
- Volume :
- 37
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
- Accession number :
- edsair.doi.dedup.....bb5501e48aae0dea5ddd6adce0c52e1c