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Interferon-beta, but not tumor necrosis factor-alpha, production in response to poly I:C is maintained despite exhaustive exercise in mice
- Source :
- The Journal of Physiological Sciences. 62:59-62
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- It remains unclear whether immune response to viral infection is inhibited by severe exercise. We determined whether exhaustive exercise inhibits interferon (IFN)-β and tumor necrosis factor (TNF)-α production after injection of synthetic double-stranded (ds) RNAs, a polyriboinosinic polyribocytidylic acid (poly I:C), as viral infection model. Male C3H/HeN mice, which were divided into exhaustive-exercised and non-exercised groups, were injected with poly I:C (5 mg/kg). Although TNF-α in response to poly I:C was significantly inhibited by exhaustive exercise, IFN-β was no different in both groups. In in-vitro experiments, catecholamines inhibited poly I:C-induced TNF-α, but not IFN-β, production in macrophages. These results suggest that anti-virus cytokine IFN-β in response to poly I:C might be maintained despite severe stressful exercise.
- Subjects :
- Male
Cell physiology
medicine.medical_specialty
Epinephrine
Physiology
Dopamine
medicine.medical_treatment
Physical Exertion
Polyriboinosinic-Polyribocytidylic Acid
Tumor necrosis factor-alpha production
Biology
Mice
Norepinephrine
Immune system
Stress, Physiological
Interferon
Internal medicine
medicine
Animals
I²C
Mice, Inbred C3H
Tumor Necrosis Factor-alpha
Macrophages
Interferon-beta
Poly I-C
Endocrinology
Cytokine
Immunology
Tumor necrosis factor alpha
medicine.drug
Subjects
Details
- ISSN :
- 18806562 and 18806546
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- The Journal of Physiological Sciences
- Accession number :
- edsair.doi.dedup.....bb4e4f27e57b3ffe48ac776a9c935c28