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The C/C_₁₃₉₁₀ and G/G_₂₂₀₁₈ Genotypes for Adult-type Hypolactasia are not Associated with Inflammatory Bowel Disease
- Source :
- Scandinavian Journal of Gastroenterology. 38:538-542
- Publication Year :
- 2003
- Publisher :
- Informa UK Limited, 2003.
-
Abstract
- Lactose intolerance with adult-onset is due to the inadequate enzymatic activity of lactasephlorizin hydrolase (LPH). It is frequently seen in patients with Crohn disease, but the mechanism remains to be elucidated. Two DNA genotypes, C/C(-13910) and G/G(-22018), located upstream from the LCT locus, the gene encoding for LPH, were recently identified as representing genetic markers for lactose intolerance. We utilized these two DNA genotypes to study their role in inflammatory bowel disease.We investigated the prevalence of these two DNA variants using specific restriction enzyme digest assays in 166 patients with Crohn disease, in 120 healthy first-degree relatives of Crohn disease patients, in 63 patients with ulcerative colitis and in 187 healthy individuals.The analysis revealed a frequency of 21.4% of the 2 genotypes for adult-type hypolactasia in our studied German cohort of healthy individuals, which is higher than previously reported (15%) based on the hydrogen (H2) breath test. This might indicate a higher sensitivity of genotyping, but it has to be confirmed in larger cohorts. No significant difference was detectable in the frequency of the C/C(-13910) and G/G(-22018) genotypes in patients with Crohn disease (C/C(-13910): 21.7%; G/G(-22018): 22.3%) compared to first-degree relatives (C/C(-13910): 21.7%; G/G(-22018): 20.8%), patients with ulcerative colitis (C/C(-13910): 20.3%; G/G(-22018): 20.3%) and healthy individuals (C/C(-13910): 21.4%; G/G(-22018): 21.4%).The C/C(-13910) and G/G(-22018) genotype of adult-type hypolactasia is not associated with susceptibility to the pathogenesis of Crohn disease and ulcerative colitis.
- Subjects :
- Adult
Genetic Markers
Male
medicine.medical_specialty
Adolescent
Genotype
medicine.medical_treatment
Inflammatory bowel disease
Gastroenterology
Cohort Studies
Lactose Intolerance
Internal medicine
Immunopathology
Prevalence
Humans
Medicine
Age of Onset
Aged
Lactose intolerance
business.industry
Lactase
Middle Aged
Inflammatory Bowel Diseases
medicine.disease
Ulcerative colitis
Food intolerance
Endocrinology
Genetic marker
Female
business
Subjects
Details
- ISSN :
- 15027708 and 00365521
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Scandinavian Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....bb3759c513621d5c0ed010b2f992123a