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Metabolomics profiling of xenobiotics in elite athletes: relevance to supplement consumption
- Source :
- Journal of the International Society of Sports Nutrition, 15:48, Journal of the International Society of Sports Nutrition, Journal of the International Society of Sports Nutrition, Vol 15, Iss 1, Pp 1-10 (2018)
- Publication Year :
- 2018
-
Abstract
- Background Supplements are widely used among elite athletes to maintain health and improve performance. Despite multiple studies investigating use of dietary supplements by athletes, a comprehensive profiling of serum supplement metabolites in elite athletes is still lacking. This study aims to analyze the presence of various xenobiotics in serum samples from elite athletes of different sports, focusing on metabolites that potentially originate from nutritional supplements. Methods Profiling of xenobiotics in serum samples from 478 elite athletes from different sports (football, athletics, cycling, rugby, swimming, boxing and rowing) was performed using non-targeted metabolomics-based mass spectroscopy combined with ultrahigh-performance liquid chromatography. Multivariate analysis was performed using orthogonal partial least squares discriminant analysis. Differences in metabolic levels among different sport groups were identified by univariate linear models. Results Out of the 102 detected xenobiotics, 21 were significantly different among sport groups including metabolites that potentially prolong exercise tolerance (caffeic acid), carry a nootropic effect (2-pyrrolidinone), exert a potent anti-oxidant effect (eugenol, ferulic acid 4 sulfate, thioproline, retinol), or originate from drugs for different types of injuries (ectoine, quinate). Using Gaussian graphical modelling, a metabolic network that links various sport group-associated xenobiotics was constructed to further understand their metabolic pathways. Conclusions This pilot data provides evidence that athletes from different sports exhibit a distinct xenobiotic profile that may reflect their drug/supplement use, diet and exposure to various chemicals. Because of limitation in the study design, replication studies are warranted to confirm results in independent data sets, aiming ultimately for better assessment of dietary supplement use by athletes.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Sports medicine
Dietary supplement
Metabolic network
Physiology
lcsh:TX341-641
Clinical nutrition
Xenobiotics
Nootropic
Athletes
Metabolomics
Nutritional supplements
Sport
Chromatography, High Pressure Liquid
Female
Humans
Sports
Tandem Mass Spectrometry
Dietary Supplements
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine
Elite athletes
lcsh:Sports medicine
Nutrition and Dietetics
business.industry
030229 sport sciences
030104 developmental biology
chemistry
lcsh:RC1200-1245
business
Xenobiotic
lcsh:Nutrition. Foods and food supply
Research Article
Food Science
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of the International Society of Sports Nutrition, 15:48, Journal of the International Society of Sports Nutrition, Journal of the International Society of Sports Nutrition, Vol 15, Iss 1, Pp 1-10 (2018)
- Accession number :
- edsair.doi.dedup.....bb2c663bb1abe57172e2ec0da061ad42