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Plasma copeptin in the assessment of febrile neutropenia
- Source :
- Peptides. 36:129-132
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Copeptin, the surrogate marker of arginine vasopressin (AVP), has been suggested to be a useful biomarker in monitoring sepsis reflecting hemodynamic imbalance and stress state. This prospective study conducted at a hematology ward in a Finnish University Hospital aimed to investigate whether plasma copeptin predicts the development of complicated course of neutropenic fever (bacteremia or need for treatment at intensive care unit) in 100 hematological patients experiencing their first neutropenic fever episode after intensive chemotherapy for hematological malignancy. Contrary to study presumptions, not elevated copeptin but the lack of a proper initial increase of plasma copeptin (0.02 ng/mL from day 0 to day 1) predicted blood culture positive sepsis (p=0.023) and gram-negative bacteremia (p=0.045). No correlation was observed with plasma sodium, blood pressure or evaluated osmolality. Plasma copeptin correlated inversely with the same day pentraxin 3 on day 0-day 2 (all p-values0.001) and with C-reactive protein on day 1 (p=0.015). In conclusion, copeptin did not correlate with disease severity, but the lack of a proper initial increase was associated with bacteremic complications of febrile neutropenia in hematological patients. The findings suggest the possibility of central dysregulation of AVP release and do not support the use of copeptin as a biomarker of septic complications in this patient group.
- Subjects :
- Adult
Male
medicine.medical_specialty
Neutropenia
Adolescent
Fever
Hydrocortisone
Physiology
Antineoplastic Agents
Bacteremia
Biochemistry
law.invention
Sepsis
Young Adult
Cellular and Molecular Neuroscience
Endocrinology
Copeptin
law
medicine
Humans
Prospective Studies
Intensive care medicine
Prospective cohort study
Aged
business.industry
Surrogate endpoint
Glycopeptides
Middle Aged
medicine.disease
Intensive care unit
Leukemia, Myeloid, Acute
Serum Amyloid P-Component
C-Reactive Protein
Biomarker (medicine)
Female
business
Biomarkers
Febrile neutropenia
Subjects
Details
- ISSN :
- 01969781
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Peptides
- Accession number :
- edsair.doi.dedup.....bb233aba8ad078a7e9379fb707eb2a43