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Coexisting neuronal autoantibodies among children with demyelinating syndromes
- Source :
- Brain and Development. 39:248-251
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Objectives To determine the incidence and clinical relevance of neuronal autoantibodies in children with demyelinating syndromes. Methods We conducted a prospective study including 31 consecutive children with demyelinating syndromes. Four patients with N-Methyl- D -aspartate receptor (NMDAR) encephalitis, 32 patients with Guillain-Barre syndrome, 13 children with benign childhood epilepsy, and 28 healthy children were used as controls. Prior to initiating immunomodulatory therapy, serum samples were tested for antibodies against NMDAR, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) 1, AMPAR2, leucine-rich glioma-activated protein 1, contactin-associated protein 2, gamma-aminobutyric acid B receptors, paraneoplastic ma antigen 2 (PNMA2/Ta), Yo, Ri, Hu, CV2, amphiphysin, and aquaporin-4 by indirect immunofluorescence assays. Results Three anti-neuronal antibodies were detected; NMDAR antibody in one with multiple sclerosis, PNMA2/Ta antibody in one with multiple sclerosis, and Yo antibody in one with clinically isolated syndrome. The positivity rate of neuronal autoantibodies in demyelinating syndrome was 10%. All seropositive patients were found to be negative for tumor screening. None of these patients exhibited symptoms of encephalitis. Conclusion Children with demyelinating syndromes without symptoms of encephalitis can be positive for anti-neuronal antibodies.
- Subjects :
- Male
0301 basic medicine
Pathology
medicine.medical_specialty
Adolescent
Nerve Tissue Proteins
Receptors, N-Methyl-D-Aspartate
03 medical and health sciences
0302 clinical medicine
Developmental Neuroscience
Antigen
medicine
Humans
Clinical significance
Prospective Studies
Child
Prospective cohort study
Autoantibodies
Epilepsy
Clinically isolated syndrome
biology
business.industry
Multiple sclerosis
Autoantibody
General Medicine
medicine.disease
030104 developmental biology
Child, Preschool
Pediatrics, Perinatology and Child Health
Immunology
biology.protein
Encephalitis
Female
Neurology (clinical)
Antibody
business
030217 neurology & neurosurgery
Demyelinating Diseases
Subjects
Details
- ISSN :
- 03877604
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Brain and Development
- Accession number :
- edsair.doi.dedup.....bb1ed0cfb1c507988ce06bd040c97fb6